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AIEgens for synergistic anticancer therapy
Journal of Materials Chemistry B, 2023To improve the precision of cancer treatment, maximize therapeutic effects, and minimize mortality, AIEgen-based synergistic therapies combining imaging technologies, phototherapy, and other therapies will be introduced and perspected in this review.
Xinyan Lyu +7 more
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Cytokines in anticancer therapy
Clinics in Dermatology, 1991Abstract Cytokines are the protein products of cells that regulate proliferation, differentiation, and functional activation. They are synthesized by a variety of cells, for example, lymphocytes, stromal cells, monocyte-macrophages, and keratinocytes. Glycoproteins such as interleukin (IL)-1, IL-2, IL-3, IL-4, IL-5, IL-6, granulocyte macrophage colony-
I U, Khan, N H, Shear
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Current Topics in Medicinal Chemistry, 2005
Escherichia coli purine nucleoside phosphorylase (PNP) catalyzes the cleavage of 9-(2-deoxy-beta-D-ribofuranosyl)-6-methylpurine (MeP-dR), while human PNP does not. MeP-dR is well tolerated while the cleavage product, 6-methylpurine (MeP), is highly cytotoxic.
Yang, Zhang +3 more
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Escherichia coli purine nucleoside phosphorylase (PNP) catalyzes the cleavage of 9-(2-deoxy-beta-D-ribofuranosyl)-6-methylpurine (MeP-dR), while human PNP does not. MeP-dR is well tolerated while the cleavage product, 6-methylpurine (MeP), is highly cytotoxic.
Yang, Zhang +3 more
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MDR Inhibitors for Anticancer Therapy
Anti-Cancer Agents in Medicinal Chemistry, 2022Peter, Werner, Andreas, Hilgeroth
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Natural products in anticancer therapy
Current Opinion in Pharmacology, 2001Many pharmaceutical agents have been discovered by screening natural products from plants, animals, marine organisms and microorganisms. Vincristine, irinotecan, etoposide and paclitaxel are examples of plant-derived compounds that are being employed in cancer treatment, and dactinomycin, bleomycin and doxorubicin are anticancer agents derived from ...
A B, da Rocha +2 more
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Docetaxel Nanotechnology in Anticancer Therapy
ChemMedChem, 2012AbstractTaxanes have been recognized as a family of very efficient anticancer drugs, but the formulation in use for the two main taxanes—Taxol for paclitaxel and Taxotere for docetaxel—have shown dramatic side effects. Whereas several new formulations for paclitaxel have recently appeared, such as Abraxane and others currently in various phases of ...
Pengxiang, Zhao, Didier, Astruc
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Inulin/oligofructose and anticancer therapy
British Journal of Nutrition, 2002The results of our investigations indicate that dietary treatment with inulin or oligofructose incorporated in the basal diet for experimental animals: (i) reduced the incidence of mammary tumors induced in Sprague-Dawley rats by methylnitrosourea; (ii) inhibited the growth of transplantable malignant tumors in mice; and (iii) decreased the incidence ...
H S, Taper, M B, Roberfroid
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Sphingolipids in Anticancer Therapy
Current Medicinal Chemistry, 2006Sphingolipids constitute a broad class of compounds with many biological functions. The sphingolipid metabolites ceramide and sphingosine are potent apoptosis inducers and produce cell cycle arrest, whereas sphingosine-1-phosphate promotes cellular growth and differentiation.
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Pharmacokinetic Optimisation of Anticancer Therapy
Clinical Pharmacokinetics, 1991It is obvious that there are great problems with pharmacokinetic individualization of anticancer therapy. The strong relationship between dose intensity (total dose/unit time) and response revealed in clinical trials with some tumours provides a strong support for studies seeking relationships between the individual plasma pharmacokinetic profile and ...
J, Liliemark, C, Peterson
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Spermine Metabolism and Anticancer Therapy
Current Cancer Drug Targets, 2009The natural polyamines (PA), putrescine (PUT), spermidine (SPD) and spermine (SPM) are ubiquitous constituents of eukaryotic cells. The increase of PA in malignant and proliferating cells attracted the interest of scientists during last decades, addressing PA depletion as a new strategy to inhibit cell growth. Selective enzyme inhibitors were developed
Amendola, R. +5 more
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