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Telomerase Inhibitors as Anticancer Therapy
Current Medicinal Chemistry-Anti-Cancer Agents, 2002Telomerase inhibitors have been touted as a novel cancer specific therapy, as most tumor cells have high expression of telomerase, whereas most normal somatic cells express low or undetectable levels of telomerase. Continued proliferation of tumor cells requires activation of telomerase to maintain chromosomal stability and extend life span, because ...
Masaharu, Akiyama +3 more
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Targeting SOX2 in anticancer therapy
Expert Opinion on Therapeutic Targets, 2018SOX2 is a transcription factor that is important in the development and maintenance of the stem cell state. Furthermore, SOX2 is associated with cancer progression because it promotes the migration, invasion, and proliferation of cancer cells. SOX2 is also expressed in cancer stem cells and appears to be involved in the resistance toward anticancer ...
Laura, Hüser +4 more
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Prodrugs in Photodynamic Anticancer Therapy
Current Pharmaceutical Design, 2011Photodynamic therapy (PDT), the concept of cancer treatment through the selective uptake of a light-sensitive agent followed by exposure to a specific wavelength, is limited by the transport of a photosensitizer (PS) to the tumor tissue. Porphyrin, an important PS class, can be used in PDT in the form of its prodrug molecule 5-aminolevulinic acid (5 ...
Robert, Musiol +2 more
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PARP inhibitors for anticancer therapy
Biochemical Society Transactions, 2014PARP-1 [poly(ADP-ribose) polymerase-1], which plays a key role in DNA repair, was discovered 50 years ago. PARPi (PARP inhibitors), originally made to probe the function of the enzyme, inhibit DNA repair and increase the potency of anticancer cytotoxic agents.
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Anticancer oral therapy: Emerging related issues
Cancer Treatment Reviews, 2010The use of oral anticancer drugs has shown a steady increase. Most patients prefer anticancer oral therapy to intravenous treatment primarily for the convenience of a home-based therapy, although they require that the efficacy of oral therapy must be equivalent and toxicity not superior than those expected with the intravenous treatment.
Banna, Giuseppe Luigi +9 more
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Nanoparticles for Anticancer Therapy
2021In the last decades, scientists around the world have been aiming their efforts to elucidate the unique properties of biocompatible nanoparticles and how to use these materials to develop new approaches for cancer treatments. Once discovered that nanoparticles can spontaneously leave the bloodstream in neoplastic sites and passively accumulate in tumor’
Marcelo Fernandes Cipreste +3 more
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Enzymes in Metabolic Anticancer Therapy
2019Cancer treatment has greatly improved over the last 50 years, but it remains challenging in several cases. Useful therapeutic targets are normally unique peculiarities of cancer cells that distinguish them from normal cells and that can be tackled with appropriate drugs.
Maggi M., Scotti C.
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Molecular Anticancer Therapies
1998Cancer results from a series of gene mutations that disrupt normal controls on cell growth. It is worth repeating this definition now, near the end of the book, in order to focus our discussion of molecular anticancer therapies. The most important result of the discoveries of molecular biology applied to cancer is knowledge.
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Targeting apoptosis for anticancer therapy
Seminars in Cancer Biology, 2015Programmed cell death via apoptosis is characteristically disturbed in human cancers. This facilitates not only tumor formation and progression, but also treatment resistance. Since many currently applied anticancer treatment strategies rely on intact cell death signaling pathways for their therapeutic efficacy, a better understanding of the regulatory
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