Results 151 to 160 of about 482,975 (382)

Risk Stratification Using the CHA2DS2‐VASc Score in Takotsubo Syndrome: Data From the Takotsubo Italian Network

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe CHA2DS2‐VASc score predicts stroke in patients with atrial fibrillation and has been reported to have a prognostic role even in acute coronary syndrome patients.
Guido Parodi, Fernando Scudiero, Rodolfo Citro, Angelo Silverio, Benedetta Bellandi, Concetta Zito, Francesco Antonini‐Canterin, Fausto Rigo, Chiara Zocchi, Eduardo Bossone, Jorge Salerno‐Uriarte, Federico Piscione, Carlo Di Mario   +12 more
doaj   +1 more source

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

Advanced Science, EarlyView.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li, Weijia Chen, Mengxue Sun, Xinbo Ni, Qishan Ran, Xiaoyu Hu, Fang Cao, Wenwen Zeng   +7 more
wiley   +1 more source

Direct Oral Anticoagulants in Patients with Obesity and Atrial Fibrillation: Position Paper of Italian National Association of Hospital Cardiologists (ANMCO) [PDF]

, 2021
David Mocini, Stefania Angela Di Fusco, Edoardo Mocini, Lorenzo M. Donini, Carlo Lavalle, Andrea Di Lenarda, Carmine Riccio, Pasquale Caldarola, Leonardo De Luca, Michele Massimo Gulizia, Fabrizio Oliva, Domenico Gabrielli, Furio Colivicchi   +12 more
openalex   +1 more source

Mucin‐Inspired Filamentous Sulfated Copolymers Effectively Inhibit Human Respiratory Syncytial Virus (hRSV) Infectivity

Advanced Science, EarlyView.
Virucidal polymers serve as effective antivirals by not only inhibiting viruses but also destroying them. Inspired by the chemical properties of mucin‐mimetics, dendronized polyglycerol‐sulfated, mucin‐inspired amphiphilic copolymers (MIACPs) have been developed.
Raju Bej, Enyu Xie, Kai Ludwig, Robert F. Schmidt, Yannic Kerkhoff, Robert Dalgliesh, Nilanjan Paul, Michael Gradzielski, Andreas Herrmann, Christian Sieben, Rainer Haag   +10 more
wiley   +1 more source

Left Atrial Appendage Thrombosis and Oral Anticoagulants: A Meta-Analysis of Risk and Treatment Response [PDF]

, 2022
Yun-Yung Cheng, Shennie Tan, Chien‐Tai Hong, Cheng‐Chang Yang, Lung Chan   +4 more
openalex   +1 more source

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

Portal Venous Thrombosis Associated with Use of Etonogestrel/ethinyl Estradiol Vaginal Ring [PDF]

, 2020
Introduction: Portal venous thrombosis is a life-threatening cause of abdominal pain. In younger patients, heritable thrombophilias, pregnancy, tobacco use, and oral contraceptives are associated.Case Report: A 26-year-old woman prescribed contraceptive ...
Bailey, Katelynn E., Tranovich, Michael J.   +1 more
core  

Non-valvular Atrial Fibrillation in CKD: Role of Vitamin K Antagonists and Direct Oral Anticoagulants. A Narrative Review [PDF]

, 2021
Aleix Cases, Pablo Gómez, José Jesús Broseta, Elisa Pérez Bernat, Juan de Dios Arjona Barrionuevo, José Pórtoles, José Luis Górriz   +6 more
openalex   +1 more source

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact

Advanced Science, EarlyView.
Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou, Yingying Zhang, Peng Zhou, Haofang Wan, Lingling Li, Bin Xu, Yuping Wan, Yingming Song, Yi Kang, Hongbo Zhang, Min Shi, Qun Hou, Jiehong Yang, Chen Ding, Wei Fu, Buchang Zhao, Haitong Wan   +16 more
wiley   +1 more source