Results 151 to 160 of about 346,610 (333)

Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the splenic clearance of PtdSer‐positive senescent and altered erythrocytes such as erythrocyte ghosts (eryghosts ...
Claire Auditeau   +26 more
wiley   +1 more source

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

open access: yesAnnals of Neurology, EarlyView.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek   +7 more
wiley   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

open access: yesAnnals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

MEW/PVA‐MA Hydrogel Vascular Grafts: Enhancing Hemocompatibility and Endothelialization

open access: yesAdvanced NanoBiomed Research, EarlyView.
A biomimetic vascular graft combining biofunctionalized PVA‐MA hydrogels with a MEW scaffold is developed for small‐diameter applications. Gel‐MA and Hep‐MA incorporation enhances endothelialization and hemocompatibility, respectively, targeting the acute biological responses.
Verena Kronberger   +8 more
wiley   +1 more source

Ulvan‐Based Electrospun Nanofibres From Water Solutions: Process Conditions and Characterisations

open access: yesJournal of Applied Polymer Science, EarlyView.
Ulvan‐based electrospun nanofibres. ABSTRACT Recently, marine biopolymers have attracted considerable attention due to their high biocompatibility and biodegradability, making them ideal candidates in biomedical fields such as wound care, drug delivery, and tissue engineering.
Jacopo Paini   +5 more
wiley   +1 more source

Anticoagulants [PDF]

open access: yesNature Reviews Cardiology, 2018
openaire   +2 more sources

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