Results 201 to 210 of about 143,207 (265)

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz, Pimrapat Gebert, Jingwen Luo, Paraskevi Tassopoulou, Juliane Bolbrinker, Antonios Douros   +5 more
wiley   +1 more source

Drugs to Prevent and Treat Venous Thromboembolic Disease During Pregnancy. [PDF]

Clin Perinatol
James AH, Federspiel JJ.
europepmc   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source

Evaluation of large language model responses to patient questions on oral anticoagulant therapy: a comparative expert assessment. [PDF]

Explor Res Clin Soc Pharm
Khan MA, Chaudhary V, Maazuddin M, Sultan I, Mehnaaz S, Pal B.   +5 more
europepmc   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review. [PDF]

World J Methodol
Rehman A, Abid M, Jamil H, Siddique S, Parkash S, Nasrullah F, Sapna F, Lohana B, Lohana K, Jawed I, Tufail M, Sharaf MS.   +11 more
europepmc   +1 more source

High‐Dimensional Spectral Flow Cytometry Panel for Immunophenotypic Characterization of Fixed Whole Blood Samples

Cytometry Part A, EarlyView.
ABSTRACT Peripheral blood mononuclear cells (PBMCs) are commonly used for immune profiling in clinical research, but their isolation and cryopreservation present logistical challenges, particularly in settings with limited access to research facilities. To address this, we implemented a whole blood fixation protocol to preserve surface protein epitopes
Vaishnavi Parthasarathy, Alexander T. Heubeck, Tyanna Stuckey, Veronica Hernandez, Blessing Musgrove, Maia M. Bennett‐Boehm, Troy Torgerson, Peter Skene, Julian Reading   +8 more
wiley   +1 more source

Direct oral anticoagulants and warfarin in atrial fibrillation patients with cancer by anticoagulation quality. [PDF]

Cancer
Menichelli D, Cormaci VMD, Gazzaniga G, Bisceglia I, Camilli M, Poli D, Antonucci E, Pola R, Santini P, Pignatelli P, Pastori D, START2 Registry Investigators.   +11 more
europepmc   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde, Yendry Ventura Carmenate, Vianed Marsan Suarez, Yandy Marx Castillo Aleman, Imilla Casado Hernandez, Rachely Hernandez Corrales   +5 more
wiley   +1 more source

Re: Systematic Scoping on Point-of-care Monitoring of Direct Oral Anticoagulants in Non-valvular Atrial Fibrillation. [PDF]

Eur Cardiol
Danjuma MI, Bassut R, Bakir L, Elshafei MN.   +3 more
europepmc   +1 more source