Results 11 to 20 of about 23,500 (169)

Cytokine transcriptome profiling in acute experimental canine atopic dermatitis skin lesions after IL‐31 inhibition with lokivetmab

Veterinary Dermatology, Volume 34, Issue 4, Page 327-338, August 2023., 2023
Background – The caninised monoclonal antibody lokivetmab (LKV), directed at interleukin (IL)‐31, is very effective at controlling pruritus in most dogs with atopic dermatitis (AD). However, evidence exists that IL‐31 is not required for the induction of acute allergic skin inflammation, which might explain why this treatment is less efficacious in ...
Chie Tamamoto‐Mochizuki, Natalie Crawford, Jordan M. Eder, Andrea J. Gonzales, Thierry Olivry   +4 more
wiley   +1 more source

Efficacy of subcutaneous allergen immunotherapy in atopic dogs: A retrospective study of 664 cases

Veterinary Dermatology, Volume 33, Issue 4, Page 321-e75, August 2022., 2022
Background –Canine atopic dermatitis (cAD) is an allergic skin disease affecting approximately 10% of dogs. Allergen immunotherapy (AIT) is currently the only treatment option able to induce tolerance to the causative allergens. Objective – To retrospectively establish the efficacy of AIT in atopic dogs.
Evelien E. M. Fennis, Catharina M. M. van Damme, Yvette M. Schlotter, Jacqueline D. Sinke, Mieke H. G. Leistra, Richard T. Bartels, Femke Broere   +6 more
wiley   +1 more source

Active surveillance and early detection of community transmission of SARS‐CoV‐2 Mu variant (B.1.621) in the Brazilian Amazon

Journal of Medical Virology, Volume 94, Issue 7, Page 3410-3415, July 2022., 2022
Abstract Through active surveillance and contact tracing from outpatients, we aimed to identify and characterize SARS‐CoV‐2 variants circulating in Porto Velho‐Rondônia, a city in the Brazilian Amazon. As part of a prospective cohort, we gathered information from 2,506 individuals among COVID‐19 patients and household contacts.
Gabriella S. Oliveira, Luciana Silva‐Flannery, Juliana F. Silva, Charlene Siza, Roberto J. Esteves, Barbara J. Marston, Juliette Morgan, Mateusz Plucinski, Tárcio P. Roca, Ana M. P. Silva, Soraya S. Pereira, Juan M. V. Salcedo, Dhelio B. Pereira, Felipe G. Naveca, Deusilene S. Vieira Dall'Acqua, Brazil Investigation Team   +15 more
wiley   +1 more source

A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client‐owned dogs with allergic dermatitis

Veterinary Dermatology, Volume 32, Issue 5, Page 477-e131, October 2021., 2021
Background – Interleukin (IL)‐31 is an important mediator in canine atopic dermatitis (cAD) and also may be dysregulated in other allergic diseases. Hypothesis/Objectives – To demonstrate the efficacy and safety of lokivetmab (canine anti‐IL‐31 monoclonal antibody) for treatment of pruritus associated with allergic dermatitis in dogs.
Leen Van Brussel, Hilde Moyaert, Monica Escalada, Sean P. Mahabir, Michael R. Stegemann   +4 more
wiley   +1 more source

Immunopathogenesis of the feline atopic syndrome

Veterinary Dermatology, Volume 32, Issue 1, Page 13-e4, February 2021., 2021
Résumé Contexte Les maladies félines supposées d’origine allergique avec des phénotypes cliniques semblables, peuvent avoir de nombreuses pathogénies différentes sous jacentes. Le phénotype clinque, l’étiologie précise et l’immunopathogénie sous jacente doivent tous être considérés si des avancées veulent être faites dans ces domaines négligés de la ...
Richard Halliwell, Frane Banovic, Ralf S. Mueller, Thierry Olivry   +3 more
wiley   +1 more source

Anticorpos naturais na paracoccidioidomicose [PDF]

, 2015
Recent attention has been focused on the natural antibodies as a component of natural immunity and as integral part of the idiotypic network. However, their functional role in different infections has rarely been studied.
Blotta, Maria Heloisa S.L., Leão, Mariella V.P., Unterkircher, Carmelinda S., Camargo, Zoilo Pires de   +3 more
core   +2 more sources

Serum canine thymus and activation‐regulated chemokine (TARC/CCL17) concentrations correlate with disease severity and therapeutic responses in dogs with atopic dermatitis

Veterinary Dermatology, Volume 31, Issue 6, Page 446-455, December 2020., 2020
Background – Thymus and activation‐regulated chemokine (TARC/CCL17) has been implicated in the pathogenesis of canine atopic dermatitis (cAD). Serum TARC concentrations are a reliable biomarker for human atopic dermatitis; however, their potential as a biomarker for cAD has not been investigated.
Ryota Asahina, Kazunori Ueda, Yuri Oshima, Toshitaka Kanei, Masahiro Kato, Masutaka Furue, Toshihiro Tsukui, Masahiko Nagata, Sadatoshi Maeda   +8 more
wiley   +1 more source

Detection and Inhibition of IgE for cross‐reactive carbohydrate determinants evident in an enzyme‐linked immunosorbent assay for detection of allergen‐specific IgE in the sera of dogs and cats

Veterinary Dermatology, Volume 31, Issue 6, Page 439-e116, December 2020., 2020
Background It has been demonstrated recently that immunoglobulin (Ig)E specific for cross‐reactive carbohydrate determinants (CCD) is present in the serum of allergen‐sensitized dogs and cats, and that these CCD‐specific antibodies might confound serological testing. Hypothesis/Objective The objective was to document the prevalence of CCD detectable in
Kenneth W. Lee, Brennan H. McKinney, Karen D. Blankenship, Daniel O. Morris   +3 more
wiley   +1 more source

Úlceras de pernas e anticorpos anticardiolipinas [PDF]

, 2011
Fenômenos pró-trombóticos são descritos em úlceras de perna de diferentes etiologias. Neste trabalho, procurou-se verificar a prevalência de anticorpos anticardiolipina nestes pacientes.
Thelma Larocca Skare
core   +1 more source

Discrepancies in the bilateral intradermal test and serum tests in atopic horses

Veterinary Dermatology, Volume 31, Issue 5, Page 390-e104, October 2020., 2020
Background – In equine atopic patients intradermal testing (IDT) and immunoglobulin (Ig)E serology are used frequently. There is little evidence regarding the reproducibility of the IDT and IgE serology in horses. Objectives – To compare the results of a simultaneously performed IDT on the left and right side of the neck in atopic horses, and to ...
Catharina M. M. van Damme, Jan van den Broek, Marianne M. Sloet van Oldruitenborgh‐Oosterbaan   +2 more
wiley   +1 more source