Results 131 to 140 of about 276,787 (297)

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants [PDF]

, 2018
Todd D. Gould, Carlos A. Zarate, Scott M. Thompson   +2 more
openalex   +1 more source

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source

Effect of concomitant administration of three different antidepressants with vitamin B6 on depression and obsessive compulsive disorder in mice models

, 2017
Azadeh Mesripour, Valiollah Hajhashemi, Athar Kuchak   +2 more
openalex   +1 more source

Drug‐Induced QT Prolongation: Associations Between Risk Classifications in a Swedish Clinical Decision Support System and Clinical Outcomes

Clinical Pharmacology &Therapeutics, EarlyView.
Potential adverse drug events can be signaled in Clinical Decision Support Systems (CDSSs). This study validated a Swedish CDSS (Janusmed Risk Profile) by investigating associations between calculated risk classifications of drugs with QT‐prolonging potential and registered related clinical outcomes.
Ola Nordqvist, Olof Björneld, Patrick Bergman, Björn Wettermark, Alisa Lincke, Marine L. Andersson, Tora Hammar   +6 more
wiley   +1 more source

Mania following ketamine abuse

Neuropsychiatric Disease and Treatment, 2016
Yuan-Yuan Lu,1 Chieh-Hsin Lin,2,3 Hsien-Yuan Lane1,2,4 1Department of Psychiatry, China Medical University Hospital, 2Graduate Institute of Clinical Medical Science, China Medical University, Taichung, 3Department of Psychiatry, Kaohsiung Chang Gung ...
Lu Y, Lin C, Lane H
doaj  

Lisdexamfetamine dimesylate augmentation for adults with major depressive disorder and inadequate response to antidepressant monotherapy: Results from 2 phase 3, multicenter, randomized, double-blind, placebo-controlled studies

, 2016
Cynthia Richards, Roger S. McIntyre, Richard H. Weisler, Angelo Sambunaris, Olga Brawman‐Mintzer, Joseph Gao, Brooke Geibel, Matthew Dauphin, Manisha Madhoo   +8 more
openalex   +1 more source

Effects of tricyclic antidepressants, selective serotonin reuptake inhibitors, and selective serotonin-norepinephrine reuptake inhibitors on the ocular surface [PDF]

, 2022
Ayna Sariyeva İsmayılov, Guler Celikel
openalex   +1 more source

Applying Machine Learning to Predict Complex Clinical Course in Youth With Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To compare the predictive performance of supervised machine learning models to logistic regression in identifying youth with eating disorders at risk of a complex clinical course based on clinical characteristics from the first treatment episode.
Stephanie Ryall, Abigail Bradley, Khaled El Emam, Nicole Obeid   +3 more
wiley   +1 more source

An adjunctive antidepressant nutraceutical combination in treating major depression: Study protocol, and clinical considerations

, 2015
Jerome Sarris, Con Stough, Chad Bousman, Jenifer Murphy, Karen Savage, Deidre J. Smith, Ranjit Menon, Suneel Chamoli, Georgina Oliver, Michael Berk, Gerard J. Byrne, Chee H. Ng, David Mischoulon   +12 more
openalex   +1 more source