Results 161 to 170 of about 294,750 (308)

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Analysis of mental health outcomes in major versus minor upper extremity amputations: a retrospective national database study. [PDF]

Arch Orthop Trauma Surg
Nedder V, Wang J, Peek K.
europepmc   +1 more source

Factors Associated with Premature Discontinuation of Antidepressant Drug Treatment in France [PDF]

, 2009
Marie Tournier, S. Boutouaba-Combe, Bernard Bégaud, Audrey Cougnard‐Grégoire, Hélène Verdoux   +4 more
openalex   +1 more source

Individual Cognitive Remediation Therapy and Individual Emotion Skills Training for Anorexia Nervosa: A Case Series Study in a Paediatric Ward

European Eating Disorders Review, EarlyView.
ABSTRACT Introduction Adolescents with anorexia nervosa (AN) often present cognitive rigidity, impaired decision‐making, and difficulties processing emotions, all of which can impede engagement in treatment. The marked rise in paediatric hospitalisations for AN during the COVID‐19 pandemic highlights the urgent need for brief, targeted interventions in
Dario Marin, Federica Tedde, Federico Muzzarelli, Paola Elisa Cogo, Lucia Giombini   +4 more
wiley   +1 more source

Understanding the Use of Atypical Antipsychotic Treatment for Major Depressive Disorder: An International Cross-Sectional Survey of Health Care Providers. [PDF]

J Clin Psychopharmacol
Hadzi Boskovic D, Kapadia S, Ardic F, Eisenberg DF, Hickey J, Rogerson O, Glen F.   +6 more
europepmc   +1 more source

An Investigation of Key Symptoms That Account for the Early Response Effect During Psychological Therapy for Eating Disorders

European Eating Disorders Review, EarlyView.
ABSTRACT Objective The early response effect, defined as a reliable symptomatic improvement during the initial phase of treatment, is the most robust predictor of recovery following eating disorder treatment. This study aimed to investigate which symptom domains mostly influence the early response effect. Methods Data from N = 232 adult patients (90.8%
Ammara Imtiaz, Caroline Bell, Glenn Waller, Jaime Delgadillo   +3 more
wiley   +1 more source

Blockade of HERG Human K⁺ Channels by the Antidepressant Drug Paroxetine

, 2014
Seung Ho Lee, Min Ji Sung, Hyang Mi Lee, Daehyun Chu, Sang June Hahn, Su‐Hyun Jo, Han Choe, Bok Hee Choi   +7 more
openalex   +2 more sources

Associations Between Preexisting Depression and Anxiety and Postoperative Outcomes Among Medicare Beneficiaries Undergoing Head and Neck Cancer Surgery

Head &Neck, EarlyView.
ABSTRACT Introduction Depression and anxiety are common in patients with head and neck cancer (HNC), but their impacts on postoperative outcomes after major HNC surgery are not well defined. We evaluated whether preexisting, clinically diagnosed depression or anxiety independently predicted short‐term postoperative outcomes among adults undergoing HNC ...
Xiaodan Hu, Daniel Gilmore, Ericka L. Erickson, Catherine T. Haring, Kyle VanKoevering, Nolan B. Seim, Stephen Y. Kang, James W. Rocco, Ann Scheck McAlearney, Lauren E. Miller   +9 more
wiley   +1 more source

Risk-managed antidepressant prescribing in primary care mental health: what pharmacogenetics can (and cannot) deliver. [PDF]

Front Med (Lausanne)
Jerjes W, Harding D, Klingbajl M.
europepmc   +1 more source

Hippocampal mossy cell involvement in behavioral and neurogenic responses to chronic antidepressant treatment

, 2019
Seo-Jin Oh, Paul Greengard, Jia Cheng, Yong‐Seok Oh   +3 more
openalex   +1 more source