Results 131 to 140 of about 288,395 (355)

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, EarlyView.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source

Risk of injury associated with the sedative potential of second‐generation antihistamines: A nationwide retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Individual second‐generation antihistamines may possess differential sedative potential due to the variability in central histamine receptor H1 occupancy. This study aimed to evaluate whether the sedative potential of second‐generation antihistamines is associated with the risk of injury during Japan's pollen season. Methods We conducted a
Jumpei Taniguchi, Shotaro Aso, So Sato, Hideo Yasunaga   +3 more
wiley   +1 more source

Antidepressant treatment and mortality risk in patients with dementia and depression: a nationwide population cohort study in Taiwan

Therapeutic Advances in Chronic Disease, 2019
Background: Dementia prevalence is increasing worldwide, and dementia is frequently comorbid with depression during its disease course. Additionally, safety concerns are rising regarding the prescription of psychotropic agents to patients with dementia ...
Jian-An Su, Chih-Cheng Chang, Hsuan-Min Wang, Ko-Jung Chen, Yao-Hsu Yang, Chung-Ying Lin   +5 more
doaj   +1 more source

Antidepressants stimulate population growth in the harpacticoid copepod Nitocra spinipes [PDF]

, 2020
Like many pharmaceuticals, antidepressants are designed in such a way that they do not degrade easily. Due to their limited breakdown capabilities, they often enter sewage systems in their active form and may even end up in the environment.
De Schamphelaere, Karel, Koch, Josef
core  

Paediatric developmental safety and the ICH E11A extrapolation of safety

British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Rebecca Racz, Sherbet Samuels, Dionna J. Green, Lynne P. Yao   +6 more
wiley   +1 more source

Use of antiemetics in early pregnancy 2012–2022: A cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aim Nausea and vomiting in pregnancy impact quality of life, yet many pregnant women feel dismissed by healthcare professionals, despite the safety of first‐line antiemetic treatments for both mother and fetus. Therefore, this study aims to describe the prevalence of patient‐reported antiemetic use in early pregnancy in Copenhagen, Denmark, the changes
Katrine Bak Wraae, Nanna Roed Ballegaard, Mie Lærkeholm Hede, Line Buchgreitz, Ane Lilleøre Rom, Hanne Kristine Hegaard, Nina Olsén Nathan   +6 more
wiley   +1 more source

Supplementary Figure 3 from The Antidepressant Sertraline Inhibits Translation Initiation by Curtailing Mammalian Target of Rapamycin Signaling [PDF]

, 2023
Chen‐Ju Lin, Françis Robert, Rami Sukarieh, Stephen W. Michnick, Jerry Pelletier   +4 more
openalex   +1 more source

Consistency and clarity of pharmacogenomic guidance in UK medicine patient information leaflets: A cross‐sectional analysis

British Journal of Clinical Pharmacology, EarlyView.
Pharmacogenomic (PGx) information has the potential to support the safe and effective use of medicines, yet there is uncertainty about how this information can be best communicated to patients. Summaries of product characteristics (SmPCs) and patient information leaflets (PILs) for all UK‐approved medicines with strong evidence supporting a PGx ...
Parth Narlawar, Chloe Ratcliffe, Videha Sharma, William G. Newman, Munir Pirmohamed, John McDermott   +5 more
wiley   +1 more source

Mendelian randomization analysis reveals causal relationship between depression, antidepressants and benign paroxysmal vertigo

Scientific Reports
Benign paroxysmal vertigo (BPV) is a common cause of dizziness, and some patients are comorbid with psychiatric disorders such as depression, requiring intervention with antidepressants.
Yayun Liao, Kejian Zhou, Zhiyan Guo, Lu Qin, Shan Deng, Hong Yang, Baohui Weng, Liya Pan   +7 more
doaj   +1 more source

Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study

Kidney Medicine
Rationale & Objective: The extent to which depression affects the progression of chronic kidney disease (CKD) and leads to adverse clinical outcomes remains inadequately understood.
Rosalba Hernandez, Dawei Xie, Xue Wang, Neil Jordan, Ana C. Ricardo, Amanda H. Anderson, Clarissa J. Diamantidis, John W. Kusek, Kristine Yaffe, James P. Lash, Michael J. Fischer, Lawrence J. Appel, MD, MPH, Jing Chen, MD, MMSc, MSc, Debbie L. Cohen, MD, Harold I. Feldman, MD, MSCE, Alan S. Go, MD, Robert G. Nelson, MD, PhD, MS, Mahboob Rahman, MD, Panduranga S. Rao, MD, Vallabh O. Shah, PhD, MS, Mark L. Unruh, MD, MS   +20 more
doaj   +1 more source