Results 191 to 200 of about 288,395 (355)

Patterns of seizure frequency reduction in clinical trial participants with lower baseline seizure frequency

open access: yesEpilepsia, EarlyView.
Abstract Objective Inclusion and exclusion criteria of clinical trials for seizures aim to select representative participants with a high enough seizure frequency to evaluate the efficacy of treatment in a relatively short double‐blind period. To inform the selection of seizure frequency‐based inclusion criteria, we evaluated the association between ...
Wesley T. Kerr   +5 more
wiley   +1 more source

Sodium‐glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real‐world cohort study

open access: yesEpilepsia, EarlyView.
Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin   +3 more
wiley   +1 more source

Dual role of spreading depolarization in an epileptic focus

open access: yesEpilepsia, EarlyView.
Abstract Objective Spreading depolarizations (SDs) are often associated with epileptic discharges. Although SDs are traditionally thought to contribute to postictal depression and termination of epileptic discharges, seizures may also occur during SDs or may even follow SDs, suggesting that interactions between SD and seizures are more complex.
Daria Vinokurova   +3 more
wiley   +1 more source

Psychopharmacology in Dermatology. [PDF]

open access: yesIndian Dermatol Online J
Katamanin O, Sharifi S, Jafferany M.
europepmc   +1 more source

Antidepressant drugs: evaluation of price variation

open access: diamond, 2015
Bhumika Patel   +2 more
openalex   +2 more sources

Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex [PDF]

open access: bronze, 2015
Laura Jiménez-Sánchez   +8 more
openalex   +1 more source

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

open access: yesEpilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha   +13 more
wiley   +1 more source

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