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Clinics in Geriatric Medicine, 1990
Depressive symptoms are common in the elderly, and depressive illness is the most common of emotional disorders in those of advanced age. This article focuses on the use of antidepressant drugs for the treatment of older depressed patients. To correctly understand the use of antidepressant drugs, it is necessary to first appreciate the medical ...
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Depressive symptoms are common in the elderly, and depressive illness is the most common of emotional disorders in those of advanced age. This article focuses on the use of antidepressant drugs for the treatment of older depressed patients. To correctly understand the use of antidepressant drugs, it is necessary to first appreciate the medical ...
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New England Journal of Medicine, 1965
EIGHT years ago the introduction of iproniazid (Marsilid) and imipramine (Tofranil) opened a new era in the treatment of depression and a new area of psychiatric controversy. Many other antidepressants have since appeared, but, despite numerous investigations, opinions on the most appropriate therapy for depression continue to differ.
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EIGHT years ago the introduction of iproniazid (Marsilid) and imipramine (Tofranil) opened a new era in the treatment of depression and a new area of psychiatric controversy. Many other antidepressants have since appeared, but, despite numerous investigations, opinions on the most appropriate therapy for depression continue to differ.
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Antidepressants and Convulsions
Journal of Clinical Psychopharmacology, 1992We reviewed available computer records and clinical charts in an estimated 42,000 recipients of antidepressant drugs. The study was restricted to persons with no known condition predisposing to convulsions. Only 16 study subjects developed a convulsive disorder that we judged could have been caused by an antidepressant.
S S, Jick +3 more
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Antidepressants and neuroplasticity
Bipolar Disorders, 2002Objective: We review the literature on the cellular changes that underlie the structural impairments observed in brains of animals exposed to stress and in subjects with depressive disorders. We discuss the molecular, cellular and structural adaptations that underlie the therapeutic responses of different classes of ...
Carrol, D'Sa, Ronald S, Duman
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A Compendium of Antidepressants
Clinical Toxicology, 1979This compendium provides a quick reference to available tricyclic antidepressants, monoamine oxidase inhibitors, lithium carbonate, and stimulants. The charts include adult dosages, drug precautions, side effects, interactions with other drugs, and effects on clinical laboratory tests. Basic information on the prevention and management of overdose with
N N, Cain, R M, Cain
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Antidepressants and the Elderly
Journal of the American Geriatrics Society, 1986The pharmacologic treatment of depression in the elderly is often complicated by cardiovascular disease and other medical illnesses. Both the tricyclic antidepressants and the monoamine oxidase (MAO) inhibitors have adverse effects that are potentially dangerous in this age group.
Peabody, CA +2 more
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Annals of the New York Academy of Sciences, 1992
Abstract Suicidal thoughts and suicide attempts are an integral part of various depressions. Suicide attempts are common in major depression but even more common in recurrent brief depression, and the rate is further increased when these depressions occur comorbidly. Combined depression, where recurrent brief depression and major depression coexist, is
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Abstract Suicidal thoughts and suicide attempts are an integral part of various depressions. Suicide attempts are common in major depression but even more common in recurrent brief depression, and the rate is further increased when these depressions occur comorbidly. Combined depression, where recurrent brief depression and major depression coexist, is
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Accident Analysis & Prevention, 1985
Although some impairment of skills due to antidepressants has been observed clinically, the impact of antidepressants on traffic safety is at present unknown.
M, Linnoila, T, Seppala
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Although some impairment of skills due to antidepressants has been observed clinically, the impact of antidepressants on traffic safety is at present unknown.
M, Linnoila, T, Seppala
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Pharmacogenetics of Antidepressants
1989The metabolism of tricyclic antidepressants is catalysed by the cytochrome P- 450 family of isozymes. The tertiary amines amitriptyline, imipramine and chlorimipramine are all demethylated to active secondary amines. Desmethylimipramine and nortriptyline, on the other hand, are hydroxylated in aromatic and benzylic positions, respectively.
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Antipsychotics as antidepressants
Asia-Pacific Psychiatry, 2015AbstractThree second‐generation antipsychotic (SGA) agents have receivedFDAapproval for adjunctive treatment, to antidepressant, of major depressive disorder: quetiapine, aripiprazole, and olanzapine. Additionally, quetiapine and lurasidone have been approved for the treatment of bipolar depression.
Rona Jeannie, Roberts +2 more
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