Results 31 to 40 of about 288,395 (355)

Molecular mechanisms of rapid-acting antidepressants: New perspectives for developing antidepressants

Pharmacological Research, 2023
Major depressive disorder (MDD) is a chronic relapsing psychiatric disorder. Conventional antidepressants usually require several weeks of continuous administration to exert clinically significant therapeutic effects, while about two-thirds of the ...
Tao Chen, Ling Cheng, Jingwen Ma, Jiyuan Yuan, Chao Pi, Linjin Xiong, Jinglin Chen, Huiyang Liu, Jia Tang, Yueting Zhong, Xiaomei Zhang, Zerong Liu, Ying Zuo, Hongping Shen, Yumeng Wei, Ling Zhao   +15 more
doaj   +1 more source

Antidepressants versus placebo for depression in primary care [PDF]

, 2009
Background Concern has been expressed about the relevance of secondary care studies to primary care patients specifically about the effectiveness of antidepressant medication.
Arroll, Bruce, Blashki, Grant, Elley, C. Raina, Fishman, Tana, Goodyear-Smith, Felicity A., Kenealy, Tim, Kerse, Ngaire, MacGillivray, Stephen   +7 more
core   +3 more sources

Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review

Acta Dermato-Venereologica, 2017
There is increasing evidence of clinically relevant anti-inflammatory effects of monoaminergic antidepressants. PubMed and Ovid databases were searched systematically for the use and efficacy of antidepressants in association with 5 common inflammatory ...
Shirin Eskeland, Jon Anders Halvorsen, Lars Tanum   +2 more
doaj   +1 more source

Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. [PDF]

, 2004
We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing.
Araki, Hiroaki, Gomita, Yutaka, Kitamura, Yoshihisa, Nagatani, Tadashi, Shibata, Kazuhiko, Takao, Katsuyuki   +5 more
core   +1 more source

Understanding Side Effects of Antidepressants: Large-scale Longitudinal Study on Social Media Data

JMIR Mental Health, 2021
BackgroundAntidepressants are known to show heterogeneous effects across individuals and conditions, posing challenges to understanding their efficacy in mental health treatment.
Saha, Koustuv, Torous, John, Kiciman, Emre, De Choudhury, Munmun   +3 more
doaj   +1 more source

General Aviation Pilots Over 70 Years Old [PDF]

, 2017
BACKGROUND: Currently it is not unusual for general aviation pilots in the United States to continue to fly beyond the age of 70, even into their 80s and 90s.
Asmayawati, Saryani, Budowle, Bruce, Griffiths, Robin, Kuoppala, Jaana, Sajantila, Antti, Strandberg, Timo, Vuorio, Alpo   +6 more
core   +1 more source

‘Never change a winning team’: GPs’ perspectives on discontinuation of long-term antidepressants

Scandinavian Journal of Primary Health Care, 2021
Background Long-term antidepressant use, much longer than recommended by guidelines, can harm patients and generate unnecessary costs. Most antidepressants are prescribed by general practitioners (GPs) but it remains unclear why they do not discontinue ...
Van Leeuwen Ellen, Sibyl Anthierens, Mieke L. van Driel, An De Sutter, Evelien van den Branden, Thierry Christiaens   +5 more
doaj   +1 more source

Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue [PDF]

, 2012
In a recent paper, Horder and colleagues (Horder et al., 2010, J Psychopharmacol 25: 1277–1288) have suggested that the mainproblem in the Kirsch analysis is methodological. We argue that the results are similar irrespective of the method used.
Bech P, Fountoulakis KN, Hans-Jürgen Möller, Kirsch I, Kirsch I, Kirsch I, Konarski JZ, Konstantinos N Fountoulakis, Moncrieff J   +8 more
core   +1 more source

Influence of mirtazapine on salivary cortisol in depressed patients [PDF]

, 2003
Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C., Hennig, J., Laakmann, G., Schule, C.   +3 more
core   +1 more source

Interventions for treating depression after stroke [PDF]

, 2008
Background: Depression is an important consequence of stroke that impacts on recovery yet is often not detected or inadequately treated. This is an update of a Cochrane review first published in 2004.
Agnoli, Ahrens, Aizawa, American Psychiatric Association, American Psychiatric Association, Andersen, Andersen, Andersen, Andersen, Andersen, Anderson, Annonymous, Astrom, Atarashi, Balunov, Bao, Battaglia, Battaglia, Bautz-Holter, Beck, Berrol, Burvill, Burvill, Burvill, Carson, Casella, Chan, Chen, Chen, Chen, Chen, Cheng, Cheng, Choi-Kwon, Choi-Kwon, Christie, Corr, Corr, Cui, Cullum, Davis, Deans, Dennis, Dennis, Desrosiers, Deutsch, Dong, Drummond, Du, Duval, Ebrahim, Evans, Evans, Feng, Feng, Fengqi, Folstein, Fruehwald, FX Project for Phase III Study, Gekht, Gekht, Gill, Goldberg, Gompertz, Gonzalez-Torrecillas, Green, Guan, Guan, Hackett, Hackett, Hackett, Hackett, Hamilton, He, He, He, Herrmann, Hollis, Hong, House, House, House, House, Hu, Hu, Huang, Huang, Hui, Hunt, Ji, Jia, Jiang, Jiang, Johnson, Johnson, Jongbloed, Jorge, Joubert, Juby, Katona, Katz, Keller, Kendall, Kimura, Kirsch, Kumar, Kwon, Lai, Lai, Laska, Latow, Lauritzen, Leff, Lehmann, Leijon, Li, Li, Li, Li, Li, Li, Li, Li, Li, Li, Liang, Liang, Lima, Lin, Lincoln, Lincoln, Lipsey, Lipsey, Liu, Liu, Liu, Liu, Liu, Lu, Mahoney, Mant, Mant, Martucci, Marui, McCusker, Meara, Meng, Miao, Min, Min, Mittmann, Miyai, Moher, Montgomery, Morris, Murray, Murray, Niedermaier, Niedermaier, Nir, Normand, Nour, Ohtomo, Ohtomo, Ostwald, Otomo, Parikh, Pearson, Ponzio, Rampello, Rampello, Rankin, Reding, Ricauda, Ricauda, Roberts, Robinson, Rodgers, Rudd, Ruddell, Rønning, Sandberg, Shan, Sharpe, Sinyor, Sivenius, Smedley, Smith, Snow, Song, Stenager, Su, Su, Sulch, Sulch, Suskin, Tan, Taragano, Taragano, Thomas, Towle, Towle, Towle, Turner-Stokes, Verhagen, Wade, Wade, Walker-Batson, Walsh, Wang, Wang, Wang, Wang, Ware, Watkins, Werner, Wheeler, Wiart, Wiart, Wilkinson, Williams, Wolfe, Wu, Xia, Xiaoying, Xie, Xie, Xie, Xing, Xu, Yang, Ye, Yi, Yoneyama, You, Young, Yu, Yu, Yu, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhao, Zhou, Zhou B. Xiao, Zhu, Zifko, Zigmond, Zimmerman   +254 more
core   +1 more source