Minocycline reduces mechanical allodynia and depressive-like behaviour in type-1 diabetes mellitus in the rat [PDF]
, 2017 A common and devastating complication of diabetes mellitus is painful diabetic neuropathy (PDN) that can be accompanied by emotional disorders such as depression.
Almeida, Armando +6 more
core +1 more source
, 2016 Advanced, anaplastic lymphoma kinase (ALK)-positive lung cancer is currently treated with the first-generation ALK inhibitor crizotinib followed by more potent, second-generation ALK inhibitors (e.g., ceritinib, alectinib) upon progression.
J. Gainor +32 more
semanticscholar +1 more source
A Skew Normal Model of the Dose-Effect Relation in Pharmacology [PDF]
arXiv, 2015 This paper deals with a skew-normal model of the relation between a dose $d > 0$ and a quantitative measure $E(d)$ of an effect of the administered drug. Precisely, $E(d)$ is a measure of the therapeutic response or a measure of a side-effect. Some existing and additional properties of the logistic functions are proved, and a skew-normal model of the ...
arxiv
, 2008 Antidepressant monotherapy is a first-line treatment for depression; however, not all sufferers will adequately respond to treatment. When treating a patient with treatment-resistant depression, the clinician needs to consider all factors which may ...
Beasley +47 more
core +1 more source
Screening for Major Depressive Disorder in Children and Adolescents: A Systematic Review for the U.S. Preventive Services Task Force [PDF]
, 2016 BACKGROUND: Major depressive disorder (MDD) is common among children and adolescents and is associated with functional impairment and suicide. PURPOSE: To update the 2009 U.S.
Forman-Hoffman, Valerie +7 more
core +2 more sources
The Role of Norepinephrine and Its α-Adrenergic Receptors in the Pathophysiology and Treatment of Major Depressive Disorder and Schizophrenia: A Systematic Review [PDF]
, 2017 Norepinephrine (NE) is recognized as having a key role in the pathophysiology of major depressive disorder (MDD) and schizophrenia, although its distinct actions via α-adrenergic receptors (α-ARs) are not well defined.
Anna Eramo +4 more
core +1 more source
Dual alpha2C/5HT1A receptor agonist allyphenyline induces gastroprotection and inhibits fundic and colonic contractility [PDF]
, 2016 Allyphenyline, a novel α2-adrenoceptor (AR) ligand, has been shown to selectively activate α2C-adrenoceptors (AR) and 5HT1A receptors, but also to behave as a neutral antagonist of α2A-ARs.
A Fletcher +81 more
core +1 more source
Venlafaxine’s effect on human genetic material: in vitro study [PDF]
, 2020 Introduction: Venlafaxine is a prescription drug approved for the treatment of major depressive disorder, generalized anxiety disorder, panic disorder and social anxiety disorder.
Chrysoglou, Sofia Ifigeneia +5 more
core +1 more source
Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials [PDF]
, 2015 Dose equivalence of antidepressants is critically important for clinical practice and for research. There are several methods to define and calculate dose equivalence but for antidepressants, only daily defined dose and consensus methods have been ...
BARBUI, Corrado +8 more
core +1 more source
Care management of the agitation or aggressiveness crisis in patients with TBI. Systematic review of the literature and practice recommendations [PDF]
, 2016 The agitation crisis in the awakening phase after traumatic brain injury (TBI) is one of the most difficult behavioral disorders to alleviate. Current treatment options are heterogeneous and may involve excessive sedation.
Luauté, Jacques +3 more
core +1 more source