Results 11 to 20 of about 24,422 (243)
Research and Practice in Thrombosis and Haemostasis, 2021 Background Bivalent thrombin‐binding aptamers (TBAs) have great potential for the treatment of thrombosis because they exhibit high anticoagulant activity, and their complementary single‐stranded DNA (ssDNA) sequences work as an antidote.
Toru Yoshitomi +3 more
doaj +1 more source
Anticoagulants: dose control methods and inhibitors
Акушерство, гинекология и репродукция, 2022 These days, anticoagulants are in great demand. They are used as a prophylaxis for thromboembolic complications in various diseases and conditions in general therapeutic practice, cardiology, neurology, as well as obstetrics to manage high-risk ...
V. O. Bitsadze +9 more
doaj +1 more source
Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction
BMC Biotechnology, 2019 Background Smoking and tobacco use continue to be the largest preventable causes of death globally. A novel therapeutic approach has recently been proposed: administration of an enzyme that degrades nicotine, the main addictive component of tobacco ...
Thomas Thisted +9 more
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A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice
Molecular Therapy: Nucleic Acids, 2023 Heparin-induced thrombocytopenia (HIT) is a complication caused by administration of the anticoagulant heparin. Although the number of patients with HIT has drastically increased because of coronavirus disease 2019 (COVID-19), the currently used thrombin
Masanobu Nagano +6 more
doaj +1 more source
Intravenous Lipid Emulsion as an Adjuvant Therapy of Acute Antipsychotic Poisoning: A randomized Controlled Trial [PDF]
Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2022 Background: Antipsychotics toxicity is one of the top five substances most frequently included in human poisoning. Various case reports documented successful use of intravenous lipid emulsion (ILE) in the management of acute antipsychotics poisoning. Aim:
Heba Lashin +3 more
doaj +1 more source
BMC Biotechnology, 2018 Background The bacterial nicotine-degrading enzyme NicA2 isolated from P. putida was studied to assess its potential use in the treatment of tobacco dependence. Results Rats were pretreated with varying i.v.
Paul R. Pentel +6 more
doaj +1 more source
Treatment of Permethrin Toxicosis in Cats by Intravenous Lipid Emulsion
Toxics, 2022 Background: In this study, the clinical response to treatment with intravenous lipid emulsion (ILE) for nine cats intoxicated with permethrin has been described.
Simona Di Pietro +5 more
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Trends in Pharmacological Sciences, 2002 This very welcome book on antidotes by Flanagan and Jones from Guy's and St Thomas' NHS Trust is a paperback, but fairly comprehensive text, on antidotes. It includes a chapter on chemical warfare agents by myself and Bob Maynard, on which I will not comment, except to say that, sadly, this chapter may prove a selling point at …
openaire +3 more sources
Antidotes for childhood toxidromes
Drugs in Context, 2021 Background: Poisoning causes significant morbidity and sometimes mortality in children worldwide. The clinical skill of toxidrome recognition followed by the timely administration of an antidote specific for the poison is essential for the management of ...
Kam Lun Hon +2 more
doaj +1 more source
Український журнал серцево-судинної хірургії, 2023 Non-vitamin K antagonist oral anticoagulants (novel oral anticoagulants, NOACs) are important pharmaceuticals for prevention of stroke and systemic embolism in non-valvular atrial fibrillation patients.
Larysa A. Vozniuk +2 more
doaj +1 more source