Results 11 to 20 of about 143,767 (270)

The effect of intravenous lipid emulsion on the outcome of aluminium phosphide poisoning [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. Due to the high lethality of aluminum phosphide as well as the lack of antidote for its treatment, this study aimed to determine the effect of intravenous lipid emulsion on the outcome of hospitalization in the patients poisoned by rice pill .
Mehdi Torabi, Zohreh Shahi moridi, Moghaddameh Mirzaee   +2 more
doaj   +1 more source

Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22

Research and Practice in Thrombosis and Haemostasis, 2021
Background Bivalent thrombin‐binding aptamers (TBAs) have great potential for the treatment of thrombosis because they exhibit high anticoagulant activity, and their complementary single‐stranded DNA (ssDNA) sequences work as an antidote.
Toru Yoshitomi, Koji Wakui, Masato Miyakawa, Keitaro Yoshimoto   +3 more
doaj   +1 more source

Anticoagulants: dose control methods and inhibitors

Акушерство, гинекология и репродукция, 2022
These days, anticoagulants are in great demand. They are used as a prophylaxis for thromboembolic complications in various diseases and conditions in general therapeutic practice, cardiology, neurology, as well as obstetrics to manage high-risk ...
V. O. Bitsadze, E. V. Slukhanchuk, J. Kh. Khizroeva, M. V. Tretyakova, V. I. Tsibizova, N. R. Gashimova, I. A. Nakaidze, I. Elalamy, J.-C. Gris, A. D. Makatsariya   +9 more
doaj   +1 more source

Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction

BMC Biotechnology, 2019
Background Smoking and tobacco use continue to be the largest preventable causes of death globally. A novel therapeutic approach has recently been proposed: administration of an enzyme that degrades nicotine, the main addictive component of tobacco ...
Thomas Thisted, Zuzana Biesova, Celine Walmacq, Everett Stone, Max Rodnick-Smith, Shaheda S. Ahmed, Stephen K. Horrigan, Bo Van Engelen, Charles Reed, Matthew W. Kalnik   +9 more
doaj   +1 more source

A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice

Molecular Therapy: Nucleic Acids, 2023
Heparin-induced thrombocytopenia (HIT) is a complication caused by administration of the anticoagulant heparin. Although the number of patients with HIT has drastically increased because of coronavirus disease 2019 (COVID-19), the currently used thrombin
Masanobu Nagano, Kazuki Kubota, Asuka Sakata, Rei Nakamura, Toru Yoshitomi, Koji Wakui, Keitaro Yoshimoto   +6 more
doaj   +1 more source

The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

BMC Biotechnology, 2018
Background The bacterial nicotine-degrading enzyme NicA2 isolated from P. putida was studied to assess its potential use in the treatment of tobacco dependence. Results Rats were pretreated with varying i.v.
Paul R. Pentel, Michael D. Raleigh, Mark G. LeSage, Thomas Thisted, Stephen Horrigan, Zuzana Biesova, Matthew W. Kalnik   +6 more
doaj   +1 more source

Treatment of Permethrin Toxicosis in Cats by Intravenous Lipid Emulsion

Toxics, 2022
Background: In this study, the clinical response to treatment with intravenous lipid emulsion (ILE) for nine cats intoxicated with permethrin has been described.
Simona Di Pietro, Annastella Falcone, Francesca Arfuso, Melissa Pennisi, Giuseppe Piccione, Elisabetta Giudice   +5 more
doaj   +1 more source

Antidotes for childhood toxidromes

Drugs in Context, 2021
Background: Poisoning causes significant morbidity and sometimes mortality in children worldwide. The clinical skill of toxidrome recognition followed by the timely administration of an antidote specific for the poison is essential for the management of ...
Kam Lun Hon, Wun Fung Hui, Alexander KC Leung   +2 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Non-Vitamin K Antagonist Oral Anticoagulants in Differentiated Approach to the Use in Cardiological Practice: Literature Review

Український журнал серцево-судинної хірургії, 2023
Non-vitamin K antagonist oral anticoagulants (novel oral anticoagulants, NOACs) are important pharmaceuticals for prevention of stroke and systemic embolism in non-valvular atrial fibrillation patients.
Larysa A. Vozniuk, Olga V. Dzekan, Sergii O. Siromakha   +2 more
doaj   +1 more source