Results 51 to 60 of about 14,058 (234)

In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon

Biomolecules, 2019
Casualties caused by organophosphorus pesticides are a burden for health systems in developing and poor countries. Such compounds are potent acetylcholinesterase irreversible inhibitors, and share the toxic profile with nerve agents.
Daniel A. S. Kitagawa, Samir F. de A. Cavalcante, Reuel L. de Paula, Rafael B. Rodrigues, Leandro B. Bernardo, Munique C. J. da Silva, Thiago N. da Silva, Wellington V. dos Santos, José M. Granjeiro, Joyce S. F. D. de Almeida, Marcos C. Barcellos, Ana Beatriz de A. Correa, Tanos C. C. França, Kamil Kuča, Alessandro B. C. Simas   +14 more
doaj   +1 more source

Opsoclonus in Pediatric Patients: Differential Diagnosis and a Practical Approach to Evaluation

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Opsoclonus is an ocular dyskinesia characterized by involuntary, arrhythmic, multidirectional saccades. In pediatrics, opsoclonus is most commonly attributed to the rare neuroinflammatory disorder opsoclonus‐myoclonus‐ataxia syndrome (OMAS), typically considered a paraneoplastic syndrome associated with neural crest tumors. However, opsoclonus
Aubrey C. Reed, Supreet S. Randhawa, Jason H. Peragallo, Prabhumallikarjun Patil, Grace Gombolay, Varun Kannan   +5 more
wiley   +1 more source

Lead detoxification of edible fungi Auricularia auricula and Pleurotus ostreatus: the purification of the chelation substances and their effects on rats

Frontiers in Nutrition, 2023
Lead is a global pollutant that causes widespread concern. When a lead enters the body, it is distributed throughout the body and accumulates in the brain, bone, and soft tissues such as the kidney, liver, and spleen.
Weiwei Zhang, Weiwei Zhang, Xiaojie Zheng, Xiangdong Chen, Xuezhen Jiang, Hexiang Wang, Guoqing Zhang   +6 more
doaj   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Support and destigmatization in early pregnancy loss in Spain

Feminist Anthropology, EarlyView.
Abstract Early miscarriages are a frequent reproductive event, often silenced and shrouded in stigma. Feminist anthropology has pointed out how such losses challenge the widespread Euro‐American social representations of motherhood and pregnancy, as well as societal unease with death.
Giulia Colavolpe‐Severi, Alexandra Desy, Carolina Remorini   +2 more
wiley   +1 more source

Antidotes to Fragility

, 2021
International audienceThe Covid crisis has revealed profound fragility in advanced societies. And yet antidotes to this fragility exist in biological, cultural and relational fields and allow us to think of a homeostasis between fragility and vitality.La
Vion-Dury, Jean
core  

Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

Chlorfenapyr Induces Hepatotoxicity Associated With Oxidative Stress and Mitochondrial Dysfunction Involving Keap1/Nrf2 Signaling

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao, Jia Li, Cheng Li, Hua He, Lipu Deng   +4 more
wiley   +1 more source

Humanism in the Age of Hyperreality: A Speculative Critique of AI Therapybots and the Neoliberal Commodification of Human Beings

The Journal of Humanistic Counseling, EarlyView.
ABSTRACT This article examines the future place of humanistic counseling, assuming the successful mass deployment of artificial intelligence therapy chatbots (AITCs). We systematically identify the limitations of AITCs through the lens of Jean Baudrillard's view on simulacra and hyperreality and identify five collective psychosocial consequences of ...
Brett. D. Wilkinson, Andrew M. Brown
wiley   +1 more source

Potential Antidotes to Phosphine Poisoning [PDF]

, 2022
Globally, phosphine gas released from metal phosphides is responsible for more poisonings (both intentional and accidental) than any other chemical agent. Metal phosphides (e.g. Ca3P2, AlP) produce phosphine through hydrolysis and can react with moisture
Garrett, Kimberly K
core