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Methodology of Antiemetic Trials [PDF]
Drugs, 1992 Progress in antiemetic research dictates that clinical trials of antiemetic agents be conducted according to guidelines for Good Clinical Practice, as follows. Studies must be of a prospective, parallel-group design in which the new treatment is compared with the existing best available treatment, after optimal dosage schedules for each have been ...
J. Gordon McVie, Karel M. de Bruijn
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Current Opinion in Oncology, 1997
In the past few years a combination of a 5-HT3 receptor antagonist plus dexamethasone has been shown to be the most efficacious antiemetic prophylaxis of acute emesis induced by cisplatin and moderately emetogenic chemotherapy. In the prevention of cisplatin-induced delayed emesis oral metoclopramide or ondansetron, both combined with dexamethasone ...
F, Roila, A, Del Favero
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In the past few years a combination of a 5-HT3 receptor antagonist plus dexamethasone has been shown to be the most efficacious antiemetic prophylaxis of acute emesis induced by cisplatin and moderately emetogenic chemotherapy. In the prevention of cisplatin-induced delayed emesis oral metoclopramide or ondansetron, both combined with dexamethasone ...
F, Roila, A, Del Favero
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Gastroenterology Clinics of North America, 1992
This article explores recent knowledge on the physiology and neuropharmacology of the emetic process. It seeks to outline the indications for specific antiemetic drugs and where their actions are targeted. Much of the information for the role of antiemetic drugs has come from experience with antiemetics in patients receiving cytotoxic chemotherapy. The
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This article explores recent knowledge on the physiology and neuropharmacology of the emetic process. It seeks to outline the indications for specific antiemetic drugs and where their actions are targeted. Much of the information for the role of antiemetic drugs has come from experience with antiemetics in patients receiving cytotoxic chemotherapy. The
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International Anesthesiology Clinics, 1994
In an editorial, Kapur [4] described perioperative nausea and vomiting as the big "little problem following ambulatory surgery." In contrast to the attitudes of some physicians, patients put a high value on freedom from nausea and emesis in the postoperative period and are willing to accept some pain and drowsiness as the cost of controlling PONV [85].
Paul F. White, Mehernoor F. Watcha
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In an editorial, Kapur [4] described perioperative nausea and vomiting as the big "little problem following ambulatory surgery." In contrast to the attitudes of some physicians, patients put a high value on freedom from nausea and emesis in the postoperative period and are willing to accept some pain and drowsiness as the cost of controlling PONV [85].
Paul F. White, Mehernoor F. Watcha
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Corticosteroids as Antiemetics
1988Although several antiemetic agents can exert some control of cancer chemotherapy-related nausea and vomiting, none is totally effective. As in many other instances of medical treatment, combinations of drugs will probably prove the best means of controlling the situation.
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Current Opinion in Oncology, 1992
Despite major progress in the treatment of chemotherapy-induced emesis, nearly one third of patients undergoing cisplatin-based regimens still experience emesis within the first 24 hours of chemotherapy. An adequate treatment of delayed and anticipatory emesis remains to be determined.
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Despite major progress in the treatment of chemotherapy-induced emesis, nearly one third of patients undergoing cisplatin-based regimens still experience emesis within the first 24 hours of chemotherapy. An adequate treatment of delayed and anticipatory emesis remains to be determined.
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Journal of Palliative Care, 1993
The choice of antiemetic should not be arbitrary, but should be based on knowledge of the different pathways of the various stimuli that lead to nausea and vomiting and the neuroreceptors involved. The steps to be taken in choosing an appropriate antiemetic are described.
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The choice of antiemetic should not be arbitrary, but should be based on knowledge of the different pathways of the various stimuli that lead to nausea and vomiting and the neuroreceptors involved. The steps to be taken in choosing an appropriate antiemetic are described.
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Methodology of trials with antiemetics
Supportive Care in Cancer, 1996Chemotherapy-induced nausea and vomiting can today be controlled with the "new" antiemetics or with their various combinations in a high percentage of patients. Despite this, for some subgroups of patients, certain chemotherapy regimens and some aspects of the phenomenon (delayed presentation), emesis remains a critical problem.
Enzo Ballatori +3 more
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Efficacy and safety of antiemetics
Cancer Treatment Reviews, 1994Of all the adverse effects associated with cancer chemotherapy, patients find nausea and vomiting the most distressing (I, 2). Indeed, nausea and vomiting continue to be critical problems in cancer chemotherapy. They can lead to a dramatic deterioration of the patients’ quality of life and result in up to 50% of patients delaying or missing treatment ...
Michel Marty, Volker Diehl
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