Results 51 to 60 of about 15,987 (195)

Repurposing the Antiemetic Metoclopramide as an Antiviral Against Dengue Virus Infection in Neuronal Cells

Frontiers in Cellular and Infection Microbiology, 2021
Dengue virus (DENV) is transmitted by Aedes mosquitoes to humans and is a threat worldwide. No effective new drugs have been used for anti-dengue treatment, and repurposing drugs is an alternative approach to treat this condition.
Ting-Jing Shen, Ting-Jing Shen, Vu Thi Hanh, Vu Thi Hanh, Vu Thi Hanh, Thai Quoc Nguyen, Thai Quoc Nguyen, Thai Quoc Nguyen, Ming-Kai Jhan, Ming-Kai Jhan, Min-Ru Ho, Min-Ru Ho, Chiou-Feng Lin, Chiou-Feng Lin, Chiou-Feng Lin   +14 more
doaj   +1 more source

Impact of timing of midazolam administration on incidence of postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery: A randomized, double-blinded, controlled study

Egyptian Journal of Anaesthesia, 2022
Background A frequently used anxiolytic, midazolam, has recently been recognized for its antiemetic activity during the perioperative period. This study sought to investigate the best time to provide midazolam in order to decrease the frequency of ...
Samar Rafik Amin, Taghreed Elshahat Sakr, Shaimaa Ezzat Amin   +2 more
doaj   +1 more source

Retrospective study of 20 cats surgically treated for insulinoma

Veterinary Surgery, Volume 52, Issue 1, Page 42-50, January 2023., 2023
Abstract Objective To report the clinical signs, histopathology results, and prognostic factors for outcomes following excision for feline insulinoma (INS). Study design Retrospective study. Sample population Twenty client‐owned cats. Methods Medical records from 2006 to 2020 were reviewed by Veterinary Society of Surgical Oncology members for cats ...
Stan Veytsman, Pierre Amsellem, Brian D. Husbands, Aaron K. Rendahl, Philip J. Bergman, Guillaume Chanoit, Colleen Hickey, Kristy R. Cash, Karl C. Maritato, Francesco Collivignarelli, Jolle Kirpensteijn   +10 more
wiley   +1 more source

Advances in Metal‐Free Transamidation: A Sustainable Approach to Amide Bond Formation

Chemistry – An Asian Journal, EarlyView.
This review highlights the recent developments of transamidation reactions under metal‐free reaction conditions. Various amines including weak nucleophilic amines such as aromatic amines have been used to achieve the transamidation reactions under mild and relatively green reaction conditions. Abstract The amide functionalities are a crucial functional
Niharan Sivaraj, Toshifumi Dohi, Fateh V. Singh   +2 more
wiley   +1 more source

Comparison of two postoperative complication grading systems after treatment of stifle and shoulder instability in 68 dogs

Veterinary Surgery, Volume 52, Issue 1, Page 98-105, January 2023., 2023
Abstract Objective (1) To adapt and apply the Clavien–Dindo (aCD) postoperative complication grading system to dogs experiencing complications following a single orthopedic procedure. (2) To compare the reliability of the Clavien–Dindo system to the Cook complication grading system. Study design Retrospective study. Sample population Sixty‐eight client‐
Faolain M. Barrett, Jason A. Bleedorn, Kyle D. Hutcheson, Bryan T. Torres, Derek B. Fox   +4 more
wiley   +1 more source

Association of the 24-hour Pregnancy Unique Quantification of Emesis Index with Self-Rated Wellbeing Score: A Cross-Sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Nausea and Vomiting of Pregnancy (NVP) are common symptoms of pregnancy. Often, treatment is guided by subjective symptoms, leading to hospitalisation of these patients and unnecessary health costs.
Nisha Bhatia, Krishna Kumari Meka, Fozia Jeelani Wani   +2 more
doaj   +1 more source

GDF15 Analogues Acting as GFRAL Ligands

ChemMedChem, EarlyView.
Considering the great importance of the GDF15/GRAL/RET signalling pathway, this review focuses on GDF15‐derived analogues able to act either as GFRAL agonists or antagonists, investigating their possible pharmacological applications in the treatment of GDF15‐related conditions, such as obesity and diabetes (agonist), or cancer‐induced nausea and ...
Andrea Di Santo, Livio Tarchi, Gianluca Villa, Giovanni Castellini, Valdo Ricca, Roberta Squecco, Anna Maria Papini, Feliciana Real‐Fernandez, Paolo Rovero   +8 more
wiley   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, EarlyView.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

Use of Real‐World Claims Data to Assess the Prevalence of Concomitant Medications to Inform Drug–Drug Interaction Risk in Target Patient Populations

Clinical Pharmacology &Therapeutics, EarlyView.
A common issue in clinical drug development involves drug–drug interactions (DDI) that may lead to altered drug exposure and subsequent altered safety and efficacy of an investigational drug or concomitant medications (conmeds) in the target patient population.
Alice S. Tang, Logan Brooks, Denise M. Boudreau, Pascal Chanu, Amita Joshi, Bianca Vora, Rui Zhu   +6 more
wiley   +1 more source

Comprehensive Qualitative Drug Screening in Emergency Toxicology Using an Automated LC–MSn System:Simultaneous Quantification of Relevant Drugs and Metabolites in Blood Plasma

Drug Testing and Analysis, EarlyView.
Simultaneous qualitative and quantitative analysis of 62 drugs and seven active metabolites in human blood plasma by automated liquid chromatography linear ion trap mass spectrometry. ABSTRACT Rapid and comprehensive qualitative and quantitative analytical procedures are crucial in 24/7 emergency toxicology (ET) to support diagnosis and treatment of ...
Selina Hemmer, Maximilian Ninnig, Lea Wagmann, Sascha K. Manier, Markus R. Meyer   +4 more
wiley   +1 more source