Results 51 to 60 of about 17,714 (234)

Bioequivalence of HTX-019 (aprepitant IV) and fosaprepitant in healthy subjects: a Phase I, open-label, randomized, two-way crossover evaluation

Drug Design, Development and Therapy, 2018
Tom Ottoboni,1 Mary Rose Keller,2 Matt Cravets,3 Neil Clendeninn,4 Barry Quart5 1Pharmaceutical and Translational Sciences, Heron Therapeutics, Inc., San Diego, CA, USA; 2Clinical Operations, Heron Therapeutics, Inc., San Diego, CA, USA; 3Biometrics ...
Ottoboni T, Keller MR, Cravets M, Clendeninn N, Quart B   +4 more
doaj  

Efficacy and safety of fruquintinib combined with albumin‐bound paclitaxel as second‐line therapy for advanced gastric cancer following failure of PD‐1 inhibitor‐containing treatment (TACTIC GC‐01): A phase II single‐arm study

International Journal of Cancer, EarlyView.
What's New? Anti‐angiogenic drugs have shown promising efficacy as a second‐line treatment for advanced gastric cancer. However, it remains unclear how alterations in the tumor microenvironment following first‐line immunotherapy may impact tumor angiogenesis and influence subsequent therapeutic outcomes. This single‐arm study prospectively explored the
Xiaoting Ma, Kai Ou, Xiu Liu, Biyang Cao, Wenwei Yang, Jingyu Lu, Letian Zhang, Qi Wang, Lizhen Gao, Zhichao Jiang, Yongkun Sun, Lin Yang   +11 more
wiley   +1 more source

Impact of Combined Additional Resections on the Surgical Outcomes of Robot‐Assisted Resection of Thymic Epithelial Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Robot‐assisted thoracoscopy (RATS) is rapidly emerging as the preferred approach for the resection of thymic epithelial tumors (TET). Current challenges include the role of RATS in locally advanced disease and combined additional resections.
Benedikt Niedermaier, Nabil Khan, Florian Eichhorn, Maria Zehentmeier, Heidrun Grosch, Raffaella Griffo, Alessio Campisi, Antonia Margineanu, Michael Allgäuer, Petros Christopoulos, Michael Thomas, Hauke Winter, Martin E. Eichhorn   +12 more
wiley   +1 more source

New antiemetic drugs

Annals of Oncology, 2006
Important progress in the prophylaxis of chemotherapy-induced acute and delayed emesis has been achieved but some fundamental needs still remain that requires new, efficacious antiemetic drugs.A critical review of the results of published studies of aprepitant, a new NK1 receptor antagonist, and of palonosetron, a 5-HT3 receptor antagonist with a ...
F, Roila, S, Fatigoni
openaire   +2 more sources

Overnight Monitoring After T&A for Children Ages 24–36 Months: Is It Always Necessary?

The Laryngoscope, EarlyView.
This study aims to identify whether all children < 3 years of age require overnight admission after tonsillectomy with or without adenoidectomy. We found that 98.7% of children who were off oxygen within 3 h after surgery never went back on oxygen during the entire monitoring period.
Tyler Van Heest, Luka Bahra, Suhong Tong, Regina Hofner‐Hnotz, Norman Friedman   +4 more
wiley   +1 more source

Inconsistency in steroid use as antiemetics in clinical trial protocols involving immune checkpoint inhibitors combined with chemotherapy

Cancer Medicine
Objectives This study aims to investigate the use of steroids as antiemetics in clinical trials involving immune checkpoint inhibitors with chemotherapy.
Soh Mee Park, Yu Jung Kim, Ju‐Yeun Lee
doaj   +1 more source

Comparison of ramosetron with ondansetron for the prevention of post-operative nausea and vomiting in high-risk patients

Indian Journal of Anaesthesia, 2015
Background and Aims: Post-operative nausea and vomiting (PONV) has an 80% incidence in high-risk patients. This is despite the availability of several antiemetic drugs.
Sandip Agarkar, Aparna S Chatterjee
doaj   +1 more source

Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System

ChemistryOpen, EarlyView.
Abietic acid (AA) reveals potent sedative potential by expressing fast sleeping onset and increased sleeping duration compare to the control group in thiopental sodium induced sleeping mice. The compound also exhibited notable binding affinity (–7.9 kcal/mol) toward GABAA receptors.
Meher Afroz, Rubel Hasan, Mst Muslima Khatun, Mokammel Hossain Tito, Md Shadin, Ranjit Chakma, Mohammed Asiri, Faisal H. Altemani, Abdullah H. Altemani, Md Shimul Bhuia, Muhammad Torequl Islam   +10 more
wiley   +1 more source

Prevention and Treatment of Postoperative Nausea and Vomiting (PONV): A Review of Current Recommendations and Emerging Therapies

Therapeutics and Clinical Risk Management, 2020
Zhaosheng Jin,1 Tong J Gan,1 Sergio D Bergese1,2 1Department of Anesthesiology, Stony Brook University Health Science Center, Stony Brook, NY 11794-8480, USA; 2Department of Neurological Surgery, Stony Brook University Health Science Center, Stony Brook,
Jin Z, Gan TJ, Bergese SD
doaj  

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, EarlyView.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source