Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance
Advanced Science, EarlyView.Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao +5 more
wiley +1 more source
Advanced Science, EarlyView.An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang +10 more
wiley +1 more source
A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines
Advanced Science, EarlyView.OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin +4 more
wiley +1 more source
Antifertility Effects of Ethanol-Extracted Turmeric on Male Rats: ELISA-Based Evaluation
Indonesian Journal of Obstetrics and GynecologyObjective: To determine the effect of administering 96% ethanol extract of turmeric (Curcuma longa Linn, syn. Curcuma domestica Val.) on the antifertility effect on male rats.
Rizka Angrainy +3 more
doaj +1 more source
Antifertility Effects of the Petroleum Ether Extract of Physalis Minima on Female Albino Rats [PDF]
, 1999 S. Sudhakaran +2 more
openalex +1 more source
Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis
Advanced Science, EarlyView.Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang +12 more
wiley +1 more source
Antifertility Effect of Passive Administration of Antibodies to 80kDa Human Sperm Antigen and its Synthetic Peptides in Male and Female Rats [PDF]
, 2005 A. H. Bandivdekar +3 more
openalex +1 more source
A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles
Advanced Science, EarlyView.A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee +6 more
wiley +1 more source
Antifertility Effects of Inorganic Iodine in Screw-Worm Flies1 [PDF]
, 1970 Maxwell M. Crystal
openalex +1 more source