Results 251 to 260 of about 3,394 (285)
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Male antifertility: An approach
Contraception, 1975Abstract Experimental data in the rat is presented for an approach to male fertility regulation. The concept involves administration of an anti-gonadotropic steroid plus a replacement androgen to inhibit spermatogenesis and to maintain normal secondary sex characteristics. A model system utilizing the adult male rat is described.
C L, Kragt +3 more
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Postcoital Antifertility Activity of Aminoalcohols
Reproductive Toxicology, 1998Previously, postcoital antifertility effects of a number of aminoalcohols, including 2-(isopropylamino)-ethanol, have been demonstrated in rodents. In this experiment, we compared the antifertility activity of 2-(isopropylamino)-ethanol to the following analogs: hydroxyethylpiperidine, hydroxyethylpiridine, hydroxyethylpirrolidine, and ...
MENEGOLA E. +3 more
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Cycloalkanones. 4. Antifertility activity
Journal of Medicinal Chemistry, 197455 mono- and di-substituted cycloalkanones were tested in female CF1 mice and several of the compounds in varying doses were tested in female Sprague-Dawley rats for their antifertility activity. Mice received 50 mg/kg/day of test drug for 28 days while rats received .1-50 mg/kg/day for 30 days.
I H, Hall +3 more
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Vegetable Antifertility Drugs of India
Quarterly Journal of Crude Drug Research, 1972A table of 76 selected species of plants which Indian medicine regards as having antifertility effects is presented. All the plants used for fertility control contain alkaloids resins tannins and bitter principles. The vulnerable points in the process of reproduction at which these plants act is not known.
B S, Malhi, V P, Trivedi
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Postcoital antifertility effect of piperine
Contraception, 1982The antifertility activity of piperine was investigated in pregnant mice when given by various routes of administration and at different periods of gestation. Piperine effectively inhibited implantation, produced abortion and delayed labor when it was given from day 2 through 5, day 8 through 12 and day 15 until labor, respectively.
P, Piyachaturawat +2 more
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Antifertility effects of antigestogens
Reproductive Medicine Review, 1993Since the discovery of the structure and function of steroids over 60 years ago, it has long been recognized that synthetic antagonists of the natural hormones would have potential therapeutic uses. Antagonists of mineralocorticoids, androgens and oestrogens, for example spironolactine, cyproterone, flutamide and tamoxifen, have already found a place ...
David T Baird, Jane E Norman
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An extragonadal male antifertility agent
Life Sciences, 1969Abstract α-Chlorohydrin produced reversible sterility in male rats. The minimally effective oral dose was 5 mg/kg/day × 14 which was 5 times lower than the anti-spermatogenic dose. The antifertility activity was apparently mediated by an effect on motility of vas deferens sperm stores.
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Antifertility factors of mammalian seminal fluid
BioEssays, 1987AbstractThe fertilizing ability of spermatozoa is inhibited by certain substances present in the seminal fluid. Most of these antifertility factors are proteinaceous in nature and differ in their physical characteristics. They inhibit fertilization by inhibiting either motility, capacitation, acrosome reaction or penetration of the ovum investments by ...
S, Shivaji, P M, Bhargava
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Properties of a spermatozoan antifertility factor
Archives of Biochemistry and Biophysics, 1967Abstract Rabbit and bull seminal plasmas were fractionated by ultracentrifugation and molecular sieving to purify decapacitation factor (DF), a substance which prevents sperm from fertilizing ova. Sedimentation in the ultracentrifuge followed by suspension of the pellet in water was repeated five times starting with rabbit seminal plasma. DF activity
M C, Pinsker, W L, Williams
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Antifertility activity of (—)-gossypol
1985Gossypol (1) is a yellow, phenolic pigment found in the cotton plant1. The compound, both in the free form and as 1:1 complexes with acetic acid and with formic acid, was discovered by the Chinese to be orally active as an antifertility agent in the male2.
S. A. Matlin, R. H. Zhou
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