Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]
Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller+31 more
core +1 more source
Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy
This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley +1 more source
Background Extracellular hydrolases (phospholipase, aspartyl protease and haemolysin) and biofilm production are considered as major virulence factors of the opportunistic pathogenic fungus Candida albicans.
Houdaii H. El-Houssaini+3 more
doaj +1 more source
The Iturin and Fengycin Families of Lipopeptides Are Key Factors in Antagonism of Bacillus subtilis Toward Podosphaera fusca [PDF]
Podosphaera fusca is the main causal agent of cucurbit powdery mildew in Spain. Four Bacillus subtilis strains, UMAF6614, UMAF6619, UMAF6639, and UMAF8561, with proven ability to suppress the disease on melon in detached leaf and seedling assays, were ...
Arrebola, Eva,+9 more
core +3 more sources
Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery
Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang+5 more
wiley +1 more source
Influence of Types Anti-Fungal Admixtures on the Concrete Mix
In recent years, the antifungal concrete is developed by using several materials as admixtures. In this present study, the antifungal activity of concrete was evaluated against specie of fungi; Aspergillus niger which can be easily discovered in the ...
Dalia Shakir Atwan
doaj
Antifungal activity of redox-active benzaldehydes that target cellular antioxidation
Background Disruption of cellular antioxidation systems should be an effective method for control of fungal pathogens. Such disruption can be achieved with redox-active compounds.
Mahoney Noreen+3 more
doaj +1 more source
Aspergillosis of the CNS in a pediatric liver transplant recipient: Case report and review [PDF]
A 2-month-old infant who had undergone orthotopic liver transplantation at the age of 2 weeks for carbamoyl phosphate synthetase deficiency developed infection of the CNS due to Aspergillus fumigatus.
Green, M+4 more
core +1 more source
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong+12 more
wiley +1 more source
An Atomically Dispersed Photocatalyst for Undirected para‐Selective C─H Bond Functionalizations
This study presents an atomically dispersed recyclable heterogeneous photocatalytic method for para‐selective trifluoromethylation of electron‐deficient arenes without directing groups. Unlike previous substrate‐dependent approaches, this recyclable, atomically dispersed photocatalyst enables scalable synthesis of bioactive trifluoromethylated ...
Suman Pradhan+16 more
wiley +2 more sources