Results 101 to 110 of about 3,492,596 (401)

Biofilm-forming capability of highly virulent, multidrug-resistant Candida auris [PDF]

, 2017
The emerging multidrug-resistant yeast pathogen Candida auris has attracted considerable attention as a source of healthcare–associated infections. We report that this highly virulent yeast has the capacity to form antifungal resistant biofilms sensitive
Borman, Andrew, Johnson, Elizabeth M., Kean, Ryan, Ramage, Gordon, Rautemaa-Richardson, Riina, Richardson, Malcolm D., Sherry, Leighann   +6 more
core   +3 more sources

Aerosolized Delivery of Antifungal Agents [PDF]

Current Fungal Infection Reports, 2010
Pulmonary infections caused by Aspergillus species are associated with significant morbidity and mortality in immunocompromised patients. Although the treatment of pulmonary fungal infections requires the use of systemic agents, aerosolized delivery is an attractive option in prevention because the drug can concentrate locally at the site of infection ...
Le, Jennifer, Schiller, Daryl S
openaire   +6 more sources

Compare the efficacy of antifungal agents as primary therapy for invasive aspergillosis: a network meta-analysis

BMC Infectious Diseases
Background Several antifungal agents are available for primary therapy in patients with invasive aspergillosis (IA). Although a few studies have compared the effectiveness of different antifungal agents in treating IA, there has yet to be a definitive ...
Ao Liu, Liubo Xiong, Lian Wang, Han Zhuang, Xiao Gan, Mengying Zou, Xiaoming Wang   +6 more
doaj   +1 more source

A review of recent developments in pharmaceutical chemistry on biological evolution of tetrazole derivatives

Al-SalamJournal for Medical Science
This review sums up the developments in the biological activity of tetrazole active derivatives in recent days. Some of the deliberated derivatives of tetrazole are at present actively scientifically studied; some of them have biological activity that ...
Zahraa A. Ketan, Halah A. R. Ibrahim, Dhuha K. Slma, Hind A. Satar, ASMAA A. JAWAD   +4 more
doaj   +1 more source

Poka: A Necro‐Robot Beetle with a Measured Payload Ratio of 6847%

Advanced Robotics Research, EarlyView.
Here, Poka, a necro‐robot beetle with the ability to carry more than 68 times its own weight, is introduced, making it also a walking robot with the highest payload ratio measured to date. This paper is concerned with the design, manufacture and validation of ‘Poka', a novel millimetre‐scale necro‐robot aimed at bridging the performance gap between ...
Yordan Tsvetkov, Parvez Alam
wiley   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids

Antimicrobial Agents and Chemotherapy, 2018
The incidence of invasive fungal infections has risen dramatically in recent decades. Current antifungal drugs are either toxic, likely to interact with other drugs, have a narrow spectrum of activity, or induce fungal resistance. Hence, there is a great
C. Lazzarini, Krupanandan Haranahalli, R. Rieger, Hari Ananthula, P. Desai, A. Ashbaugh, M. Linke, M. Cushion, B. Ruzsicska, J. Haley, I. Ojima, M. Del Poeta   +11 more
semanticscholar   +1 more source

Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]

, 2019
Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller, Altamirano, Arechavala, Bicanic, Bicanic, Boeva, Chang, Chen, Dannaoui, DePristo, Drusano, Harrison, Li, Longley, Loyse, Martin, Mayanja-Kizza, McKenna, Molloy, Mondon, Neely, Nixon, Nussbaum, Saag, Sionov, Sionov, Stone, Stott, Stott, Sudan, Wiederhold, Witt   +31 more
core   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus [PDF]

, 2017
This work was supported by Medical Mycology Section, Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Seyedmousavi, Seyedmojtaba, van der Lee, Henrich, Verweij, Paul, Warris, Adilia   +3 more
core   +1 more source