Results 121 to 130 of about 3,492,596 (401)
APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. [PDF]
, 2019 Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed ...
Alkhazraji, Sondus +7 more
core
Molecules, 2010 This review provides a historical overview of the analog based drug discovery of miconazole and its congeners, and is focused on marketed azole antifungals bearing the generic suffix “conazole”.
Jan Heeres, Lieven Meerpoel, Paul Lewi
doaj +1 more source
Advanced Science, EarlyView.Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye +13 more
wiley +1 more source
Surface modified sulfur nanoparticles can escape the glutathione reductase mediated detoxification system in fungi [PDF]
arXiv, 2015 The antifungal effects of orthorhombic (~10 nm; spherical) and monoclinic (~50 nm; tetrapod) sulfur nanoparticles (SNPs) were studied against the NADPH-dependent glutathione reductase (GR) mediated xenobiotic detoxification system (GSH-GSSG) in filamentous fungi (Aspergillus niger as a model organism).
arxiv
Lactic Acid Bacteria as Antifungal and Anti-Mycotoxigenic Agents: A Comprehensive Review.
Comprehensive Reviews in Food Science and Food Safety, 2019 Fungal contamination of food and animal feed, especially by mycotoxigenic fungi, is not only a global food quality concern for food manufacturers, but it also poses serious health concerns because of the production of a variety of mycotoxins, some of ...
F. A. Sadiq +5 more
semanticscholar +1 more source
Continuous Flow Synthesis of Nitrofuran Pharmaceuticals Using Acetyl Nitrate
Angewandte Chemie, EarlyView.A robust, automated continuous flow system enables safe, high‐yield nitration of furfural to key nitrofuran intermediates using in situ acetyl nitrate generation. Demonstrated on representative essential World Health Organization (WHO) active pharmaceutical ingredients (API), this innovative open‐source platform ensures rapid synthesis, enhanced safety,
Hubert Hellwig +8 more
wiley +2 more sources
Potential control of forest diseases by solutions of chitosan oligomers, propolis and nanosilver [PDF]
, 2017 Producción CientíficaThere is a growing necessity to replace chemical agents with ecofriendly materials, arising from the impact on the environment and/or human health, which calls for the design of new broad-spectrum fungicides.
Díez Casero, Julio Javier +5 more
core +1 more source
Tissue Penetration of Antifungal Agents [PDF]
Clinical Microbiology Reviews, 2014 SUMMARY Understanding the tissue penetration of systemically administered antifungal agents is critical for a proper appreciation of their antifungal efficacy in animals and humans. Both the time course of an antifungal drug and its absolute concentrations within tissues may differ significantly from those observed in the bloodstream.
Felton, Timothy +2 more
openaire +3 more sources
Solid lipid nanoparticles, an effective carrier for classical antifungal drugs
Saudi Pharmaceutical Journal, 2023 Solid-lipid nanoparticles (SLNs) are an innovative group of nanosystems used to deliver medicine to their respective targets with better efficiency and bioavailability in contrast to classical formulations.
Saud Almawash
doaj
Memorias do Instituto Oswaldo Cruz, 2012 The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C.
Débora Alves Nunes Mario +6 more
doaj +1 more source