Results 141 to 150 of about 42,196 (291)

A Synthetic β‐Mannan Epitope Enables Immunization and Detection of Candida auris

Angewandte Chemie, EarlyView.
A synthetic β‐mannan epitope enables both active and passive immunization against Candida auris. Conjugation to the carrier protein CRM197 induces protective antibody responses, while monoclonal antibodies targeting the same epitope support detection using a lateral flow assay, linking glycochemistry with antifungal prevention and diagnostics ...
Emelie E. Reuber, Arnab Pradhan, Ian Leaves, Rajat K. Singh, Emer Hickey, Carola Geiler, Neil A. R. Gow, Alistair J. P. Brown, Peter H. Seeberger   +8 more
wiley   +2 more sources

A Comprehensive In Vitro Approach for Assessing the Physiological Degradation of Medical Implants: The Silkothane Arteriovenous Graft Case Study

Advanced NanoBiomed Research, EarlyView.
Evaluating the degradation of absorbable medical devices in vitro demands physiologically relevant conditions. This study presents a comprehensive framework applied to a three‐layered silk fibroin/polyurethane arteriovenous graft, employing human enzymes at physiological concentrations over 6 months. Multiparametric analyses of both graft structure and
Cristina Oldani, Alice Caldiroli, Federica Barzaghi, Nina Bono, Gabriele Candiani, Stefania Adele Riboldi   +5 more
wiley   +1 more source

Successful treatment of severe influenza-associated pulmonary aspergillosis with invasive tracheobronchitis and bronchial asthma using combination antifungals and omalizumab: A case report. [PDF]

IDCases
Du W, Lv H, Ni Y, Ding Y.
europepmc   +1 more source

Impact of Azole Antifungals on the Conversion Ratio of Immediate-release Tacrolimus to LCP-Tacrolimus Tablets in Non-kidney Solid Organ Transplant Recipients. [PDF]

Transplant Direct
Lucarelli S, Lichvar A, Le T, Kerr J, Kozuch J, Tsunoda SM, Feist A.   +6 more
europepmc   +1 more source

Efficacies of Conventional Antifungals and Complementary and Alternative Medicine as Single or Combination Therapies Against <i>Candida</i> Biofilms in Recurrent Vaginal Candidiasis: An In Vitro Study. [PDF]

J Fungi (Basel)
Pan Y, Ye L, Chen L, Hermann L, Jin P, Cai Y, Cheng Y, Zhang W, Watson CJ, McGiffin D, Luo Q, Zhu X, Qu Y.   +12 more
europepmc   +1 more source

Update on therapeutic drug monitoring of antifungals for the prophylaxis and treatment of invasive fungal infections

, 2017
: Purpose of Review Certain antifungals used as therapy for invasive fungal disease, including the extended-spectrum triazoles, may be limited by variable pharmacokinetics and drug interactions.
Wiederhold, Nathan P., Schwartz, Ilan
core  

Longitudinal changes in laboratory parameters and QTc during isavuconazole therapy in Japanese patients with hematologic malignancies. [PDF]

PLoS One
Ohata K, Kobayashi R, Watanabe D, Yamada Y, Niwa T, Wada M, Ohashi M, Kaneda Y, Ikoma Y, Matsumoto T, Nakamura N, Nakamura H, Kanemura N, Shimizu M, Suzuki A.   +14 more
europepmc   +1 more source

Plasma Microbial Cell-Free DNA Sequencing for the Diagnosis of Chronic Disseminated Candidiasis in Patients with Hematologic Malignancies. [PDF]

Open Forum Infect Dis
De La Hoz A, Kovac V, Woolley AE, Issa NC, Letourneau A, Baden LR, Hammond SP, Little JS.   +7 more
europepmc   +1 more source

Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase

Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and emerging resistances. Next-generation antifungals therefore are needed urgently.
Connie B. Nichols (9176144), Yuqian Shi (10223687), Homme W. Hellinga (232290), You Wang (312086), J. Andrew Alspaugh (8307360), Feng Xu (89016), Mark D. Distefano (559344), Lorena S. Beese (1330794)   +7 more
core   +1 more source

Comment on "Accuracy of CYP3A5 Pharmacogenomics Recommended Dosing of Tacrolimus with Concomitant Azole Antifungals Early Post-Lung Transplant". [PDF]

Clin Transplant
Pandey P, Mishra AK, Singh S.
europepmc   +1 more source