Results 61 to 70 of about 1,033,264 (210)

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, EarlyView.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies

European Journal of Immunology, Volume 55, Issue 12, December 2025.
Murine allergy model outcomes differ by sensitization route, allergen type, and mouse strain, influencing mechanisms such as IgE and mast cell involvement and the therapeutic relevance of each model. Understanding how experimental parameters shape outcomes is essential for selecting appropriate models and effectively translating findings to clinical ...
Yuka Nagata, Ryo Suzuki
wiley   +1 more source

Assessment of Allergen-Induced Respiratory Hyperresponsiveness before the Prescription of a Specific Immunotherapy

Allergy & Rhinology, 2015
Background Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. Objective The aim of this study was to appreciate and correlate the local and spirometric changes elicited by ...
Celso Eduardo Olivier M.D., Ph.D., Daiana Guedes Pinto Argentão B.Biomed, Regiane Patussi dos Santos Lima B.Biomed, Mariana Dias da Silva Pharm.D., Raquel Acácia Pereira Gonçalves dos Santos B.S.N., Natalia Fabbri D.Physio, Ph.D.   +5 more
doaj   +1 more source

Th17 responses are not altered by natural exposure to seasonal allergens in pollen-sensitive patients [PDF]

, 2016
Background: Allergic rhinitis affects 10–30 % of the global population and this number is likely to increase in the forthcoming years. Moreover, it commonly co-exists with allergic asthma as a chronic allergic respiratory syndrome. While the involvement
Czesnikiewicz-Guzik, Marta, Jasiewicz-Honkisz, Barbara, Maciag, Joanna, Matusik, Pawel T., Mikolajczyk, Tomasz, Osmenda, Grzegorz, Sagan, Agnieszka, Schramm, Agata, Siedlinski, Mateusz, Sliwa, Tomasz, Wilk, Grzegorz   +10 more
core   +3 more sources

Allergic Sensitization Worsens Respiratory Health in Children With Asthma During Dust and Pollen Periods

Pediatric Pulmonology, Volume 60, Issue 12, December 2025.
ABSTRACT Background The Eastern Mediterranean has climatic conditions that increase exposure to aeroallergens due to higher pollen counts and dust storms. The association of atopy with measures of respiratory health, including fractional exhaled nitric oxide (FeNO) and pulmonary function among asthmatic children during dust and pollen periods has not ...
Yinying Qian, Eric Garshick, Emmanouil Galanakis, Eleni Michaelidou, Stefani Zembashi, Egli Costi, Antonis Michanikou, Paraskevi Kinni, Petros Koutrakis, Panayiotis K. Yiallouros, Constantinos Pitsios   +10 more
wiley   +1 more source

The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children

Respiratory Research, 2010
Background The elucidation of factors that trigger the development of transient wheezing in early childhood may be an important step toward understanding the pathogenesis of asthma and other allergic diseases later in life.
Alcântara-Neves Neuza M, Badaró Samuel J, dos Santos Mariese CA, Pontes-de-Carvalho Lain, Barreto Maurício L   +4 more
doaj   +1 more source

Prevalence and risk factors for atopic disease in a population of preschool children in Rome: Challenges to early intervention [PDF]

, 2016
Background: Allergic diseases are complex identities determined by an interplay of genetic and environmental factors, resulting in the clinical manifestation of the disease.
DE CASTRO, Giovanna, DE VITTORI, Valentina, Duse, Marzia, Forastiere, F, Indinnimeo, Luciana, Melengu, T, Porta, D, Tancredi, Giancarlo, Zicari, Anna Maria   +8 more
core   +1 more source

In vitro antigen-specific sulphidoleukotriene production in patients allergic to Dermatophagoides pteronyssinus

Revista de Medicina de la Universidad de Navarra, 1998
BackgroundSulphidoleukotrienes (slt) are important mediators in allergic diseases that are synthesized after allergen‐specific stimulation.ObjectivesThe aim of this study is to determine in vitro slt production after allergen‐specific (Dermatophagoides pteronyssinus) stimulus of peripheral blood leucocytes and to observe whether histamine release in ...
M, Ferrer, M L, Sanz, I, Prieto, A, Oehling   +3 more
openaire   +2 more sources

Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable [PDF]

, 2016
__Background:__ Allergic asthma is characterized by a TH2 response induced by dendritic cells (DCs) that present inhaled allergen. Although the mechanisms by which they instruct TH2 differentiation are still poorly understood, expression of the Notch ...
Amsen, D. (Derk), Bruijn, M.J.W. (Marjolein) de, Hendriks, R.W. (Rudi), Kleinjan, A. (Alex), Li, B.W.S. (Bobby), Lukkes, M. (Melanie), Nimwegen, M. (Menno) van, Tindemans, I. (Irma)   +7 more
core   +1 more source

Methacholine hyperresponsiveness in mice with house dust mite‐induced lung inflammation is not associated with excessive airway constriction ex vivo

Experimental Physiology, Volume 110, Issue 9, Page 1336-1348, September 1, 2025.
Abstract The role of excessive airway constriction in the hyperresponsiveness to nebulized methacholine in mice with experimental asthma is still contentious. Yet, there have been very few studies investigating whether the increased in vivo response to methacholine caused by experimental asthma is associated with a corresponding increase in ex vivo ...
Andrés Rojas‐Ruiz, Magali Boucher, Cyndi Henry, Louis Gélinas, Rosalie Packwood, Percival Graham, Jorge Soliz, Ynuk Bossé   +7 more
wiley   +1 more source