Results 131 to 140 of about 1,329,225 (354)
Targeting Inflammatory T Cells in Multiple Sclerosis: Current Therapies and Future Challenges [PDF]
, 2015 Multiple Sclerosis (MS) is an autoimmune inflammatory disorder of the Central Nervous System (CNS), affecting more than one million people worldwide. The pathogenesis of MS involves several genetic and environmental factors, which ultimately lead to ...
Tuosto, Loretta
core +1 more source
The physiological expression of inducible nitric oxide synthase (iNOS) in the human colon [PDF]
, 2001 Inducible nitric oxide synthase (iNOS) is expressed in the colonic epithelium in both inflammatory bowel disease and colorectal cancer. Nitric oxide (NO), the product of this enzyme, has been implicated in the pathogenesis of both conditions.
Hunter, JO +5 more
core +2 more sources
American Journal of Clinical Pathology, 2004 Agranular CD4/CD56 hematodermic neoplasm (CD4/CD56 HN), also termed blastic natural killer cell lymphoma, is characterized by a peculiar immunophenotype and high skin tropism.
T. Petrella +8 more
semanticscholar +1 more source
Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance
Molecular Oncology, EarlyView.In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang +8 more
wiley +1 more source
Platelets, 2018 Chronic Myelogenous Leukemia (CML) is a myeloproliferative neoplasm characterized by proliferation of Philadelphia positive clonal pluripotent hematopoietic cells. Bleeding is a rare presentation of CML that can occur due to platelet dysfunction.
Richa Chauhan +10 more
doaj +1 more source
HLA and skin cancer HLA e câncer de pele
Anais Brasileiros de Dermatologia, 2012 Skin cancer - melanoma and non melanoma - are common neoplasm with rising incidence over the last decades. It is an important public health problem. Its pathogenesis is not completely understood and the same happens with the genetic factors involved. The
Renan Rangel Bonamigo +4 more
doaj +1 more source
Discrimination of Membrane Antigen Affinity by B cells Requires Dominance of Kinetic Proofreading over Serial Triggering [PDF]
arXiv, 2010 B cells receptor (BCR) signaling in response to membrane-bound antigen increases with antigen affinity, a process known as affinity discrimination. We use computational modeling to show that B cell affinity discrimination requires that kinetic proofreading predominate over serial engagement.
arxiv
Dynamics-based peptide-MHC binding optimization by a convolutional variational autoencoder: a use-case model for CASTELO [PDF]
arXiv, 2020 An unsolved challenge in the development of antigen specific immunotherapies is determining the optimal antigens to target. Comprehension of antigen-MHC binding is paramount towards achieving this goal. Here, we present CASTELO, a combined machine learning-molecular dynamics (ML-MD) approach to design novel antigens of increased MHC binding affinity ...
arxiv
Lesions of pemphigus vulgaris on irradiated skin [PDF]
, 2009 Summary Pemphigus vulgaris (PV) is an autoimmune blistering disease produced by IgG autoantibodies against desmoglein (Dsg)3. Lesions on the skin and mucosa can, in rare cases, be induced by radiotherapy.
Aguado, L. (Leyre) +4 more
core +1 more source
Journal of Clinical and Experimental Hematopathology, 2013 Both interdigitating cell sarcoma (IDCS) and follicular dendritic cell sarcoma (FDCS) are rare neoplasms derived from dendritic cells in lymphoid organs.
H. Ohtake, M. Yamakawa
semanticscholar +1 more source