Results 151 to 160 of about 1,329,225 (354)

Phase 1 Trial of Vaccination with Autologous Tumor Cells and Antisense Directed Against the Insulin Growth Factor Type 1 Receptor (IGF-1R AS ODN) in Patients with Recurrent Glioblastoma [PDF]

, 2018
Background: Extending a previous Phase I study, we report the results of a second Phase I autologous tumor cell vaccination trial for patients with recurrent glioblastomas (IND 14379-101, NCT01550523). Methods: Following surgery, subjects were treated by
Andrews MD, David W., Harshyne, PhD, Larry, Hooper, PhD, D. Craig, Judy, MD, Kevin   +3 more
core   +2 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

HLA-G high-expressor 3’UTR markers are linked to gastric cancer development and survival

Cancer Immunology, Immunotherapy
Gastric cancer ranks fifth in both world prevalence and lethality, with a 5-year survival of less than 30%. HLA-G, a non-classical class I HLA gene, has emerged as a potential marker for cancer susceptibility and prognosis due to its immunomodulatory ...
Christian Vaquero-Yuste, Ignacio Juarez, Marta Molina-Alejandre, Elisa María Molanes-López, Alberto Gutiérrez-Calvo, Adela López-García, Inmaculada Lasa, Remedios Gómez, Antonio Arnaiz-Villena, Jose Manuel Martín-Villa   +9 more
doaj   +1 more source

Pulmonary Aspergillosis: An Evolving Challenge for Diagnosis and Treatment

Infectious Diseases and Therapy, 2020
Aspergillus is a mold that may lead to different clinical pictures, from allergic to invasive disease, depending on the patient’s immune status and structural lung diseases.
Alessandro Russo, Giusy Tiseo, Marco Falcone, Francesco Menichetti   +3 more
doaj   +1 more source

A General Theory for Direct Quantitative Analysis of Antigen [PDF]

arXiv, 2011
A theory for direct quantitative analysis of an antigen is proposed. It is based on a potential homogenous immunoreaction system. It establishes an equation to describe the concentration change of the antigen and antibody complex. A maximum point is found in the concentration profile of the complex which can be used to calculate the concentration of ...
arxiv  

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

A comparative immunohistochemical study of Ki-67 and Bcl-2 expression in solid ameloblastoma and adenomatoid odontogenic tumor

Dental Research Journal, 2012
Background: Solid ameloblastoma (SAB) is an invasive tumor which infiltrates adjacent normal tissues. Adenomatoid odontogenic tumor is a noninvasive tumor and never infiltrates surrounding normal tissues.
Sayed Mohammad Razavi, Sayed Hosein Tabatabaie, Ali Tavakoli Hoseini, Ehsan Tavakoli Hoseini, Arezu Khabazian   +4 more
doaj   +1 more source

Mediastinal syndrome from plasmablastic lymphoma in human immunodeficiency virus and human herpes virus 8 negative patient with polycythemia vera: a case report [PDF]

, 2017
Background: Plasmoblastic lymphoma is a rare and aggressive subtype of diffuse large B cell lymphoma, which occurs usually in the jaw of immunocompromised subjects.
Anzalone, A., Bruno, A., Buscemi, Salvatore, CABIBI, Daniela, CAJOZZO, Massimo, Caronia, FP, COCCHIARA, Gerlando, DAMIANO, Giuseppe, DIOGUARDI, Salvatore, Fatica, F., FLORENA, Ada Maria, LO MONTE, Attilio Ignazio, PALUMBO, Vincenzo Davide, Raffaele, F.   +13 more
core   +1 more source

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

The use of quantum dots to amplify antigen detection [PDF]

arXiv, 2017
Proposal to develop an Improved immunological assay employing primary IgG antibodies and secondary IgM antibodies labeled with quantum dots to amplify antigen detection.
arxiv