Results 241 to 250 of about 131,754 (303)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Integrating biocomputational techniques for vaccine development for glioblastoma multiforme: a possible way of enhancing precision. [PDF]

Front Immunol
Alare K, Odunitan T, Alare T, Ojo T, Alare F, Uthman U.   +5 more
europepmc   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

DLK1: a novel therapeutic target in cancer. [PDF]

Endocr Relat Cancer
Pittaway JFH.
europepmc   +1 more source

PSCA CAR Vδ1 T cells: a safer off-the-shelf CAR T therapy for pancreatic cancer? [PDF]

J Immunother Cancer
Fraietta JA, Lohmueller JJ.
europepmc   +1 more source

Emerging Applications of CAR-T Cell Therapy in Overcoming Resistance and Expanding Targets in Hematologic Malignancies: Insights from Recent Research. [PDF]

Curr Treat Options Oncol
Alipourfard I, Shafaghat Z, Saharkhiz S, Farani MR, Bakhtiyari S.   +4 more
europepmc   +1 more source

Enhanced mRNA vaccine combined with immune checkpoint blockade efficiently suppresses tumor growth and metastasis. [PDF]

J Nanobiotechnology
Zhang Y, Ma X, Jin D, Liu S, Song T, Du S, Liu Z, Lin J.   +7 more
europepmc   +1 more source

Recent developments in cancer immuno-interception strategies. [PDF]

Trends Mol Med
Zhu Z, Mathew J, Barrett B, Wang HH, Huff AL, Armstrong TD, Jaffee EM, Zaidi N.   +7 more
europepmc   +1 more source

NR2F6-modified CAR T cells drive extrinsic immunogenic cell death and antigen-agnostic immunity in solid tumors. [PDF]

Mol Ther Oncol
Klepsch V, Wolf D, Baier G.
europepmc   +1 more source

Tumor-infiltrating T Lymphocytes Recognize Thyroid-specific Proteins and Neo-antigens in Follicular Cell-derived Thyroid Cancers.

J Clin Endocrinol Metab
Garza B, Calhoun J, Norman PJ, Cline N, Kichula KM, Farias TDJ, Sams S, Boorgula MP, Danhorn T, Haugen BR, French JD.   +10 more
europepmc   +1 more source