Results 241 to 250 of about 580,546 (312)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Case Report: Allogeneic hematopoietic stem cell transplantation in a patient with triple-allele expression at both HLA-B and HLA-C loci. [PDF]

Front Immunol
Fujita Y, Yoshihara K, Takahashi D, Tanaka H, Kino Y, Yamagata F, Samori M, Takahashi S, Yoshihara S.   +8 more
europepmc   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

Biodetection of Mycobacterium tuberculosis: nano-biosensors in detection; from principles to recent progresses. [PDF]

J Biol Eng
Jooya H, Yavari S, Meskini M, Mousavi-Sagharchi SMA, Siadat SD, Mavaei M.   +5 more
europepmc   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Immunoproteomic Identification and Vaccine Assessment of <i>Trypanosoma vivax</i> Invariant Surface Glycoprotein. [PDF]

Vaccines (Basel)
Díaz GF, Rossini L, Cusinier Y, Arias DG, Bontempi I.   +4 more
europepmc   +1 more source

Discovery of tumor antigens in renal cell carcinoma and prospects for clinical application. [PDF]

Front Immunol
Kagirova E, Enikeeva K, Mukhamadeev R, Asadullina D, Sharifyanova Y, Shmelkova P, Gainullina D, Trifonova D, Gattinger P, Docena G, Dubovets A, Tulaeva I, Karaulov A, Valenta R, Pavlov V.   +14 more
europepmc   +1 more source

B7-H3 and GD2 overexpression as immunotherapeutic targets in retinoblastoma. [PDF]

Sci Rep
Sujjitjoon J, Ng WL, Kongkla K, Jarutatsanangkoon K, Chongsutakawewong K, Subhadhirasakul S, Uiprasertkul M, Udompunturak S, Junking M, Yenchitsomanus PT, Atchaneeyasakul LO.   +10 more
europepmc   +1 more source

Antigen anisotropy: The overlooked geometric determinant of vaccine immunogenicity and fidelity. [PDF]

Hum Vaccin Immunother
Santiago D.
europepmc   +1 more source