Results 121 to 130 of about 71,170 (384)

Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors

open access: yesChemistryOpen, EarlyView.
This work investigates the selective inhibition of MAO enzymes by varying the substitution of electron‐withdrawing and donating groups on the phenyl rings of tetrahydropyridines (4 a–4 o). Compounds 4 l and 4 n exhibit promising IC50 values of 0.40±0.05 and 1.01±0.03 μM against MAO‐A and MAO‐B, respectively.
Obaid ur Rehman Khan   +10 more
wiley   +1 more source

Reversible dementia due to Neurocysticercosis: improvement of the racemose type with antihistamines

open access: yesDementia & Neuropsychologia
Infection of the human central nervous system (CNS) by the larvae of Taenia solium, termed neurocysticercosis (NCC), is endemic in most developing countries, where it is a major cause of acquired seizures and other neurological morbidity, including ...
Gislaine Cristina Lopes Machado-Porto   +4 more
doaj   +1 more source

Experience of Using Levocetirizine in Pediatric Practice

open access: yesZdorovʹe Rebenka, 2014
The paper represents the latest views on antihistamine drugs use in pediatrics. For today, the most essential issue at acute and chronic allergic diseases in children is the use of new antihistamine drug — levocetirizine.
Yu.V. Marushko
doaj   +1 more source

Multimodal management of PD‐L1 positive sinonasal inverted papilloma with malignant transformation

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
Abstract Inverted papillomas (IP) are rare sinonasal tumors (Schneiderian papillomas) characterized by local invasion, with high recurrence rates and potential for malignant transformation into squamous cell carcinoma (SCC ex‐IP). Traditionally, the mainstay of treatment has been surgical resection, often challenging due to invasion of the skull base ...
Vanessa Velazquez   +3 more
wiley   +1 more source

Establishment of a human nasal epithelium model of histamine-induced inflammation to assess the activity of fexofenadine as an inverse agonist and its link to clinical benefit

open access: yesFrontiers in Pharmacology
BackgroundFexofenadine (FEX) is an antihistamine that acts as an inverse agonist against histamine (HIS) receptor 1 (H1R), which mediates the allergic reaction.
Anne Barbot   +7 more
doaj   +1 more source

Standards for MicroED

open access: yesActa Crystallographica Section C, EarlyView.
With an increasing number of refined MicroED structures available to the community, lessons can be learned of their profiles and quality, as well as of best practices.As the electron diffraction technique MicroED gains momentum and is increasingly embraced by researchers in both academia and industry, we have the opportunity to familiarize ourselves ...
Johan Unge   +3 more
wiley   +1 more source

Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement. [PDF]

open access: yes, 2013
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP.
Bain, MD   +5 more
core   +1 more source

An overview of allergy and sinusitis

open access: yesSouth African Family Practice, 2017
Allergic diseases affect many people across the globe. They are considered to significantly disturb the quality of life of the people who are affected, creating personal and economic predicaments.
Nicholus Magongwa, Natalie Schellack
doaj   +1 more source

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