Results 251 to 260 of about 23,450 (303)
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Journal of Allergy and Clinical Immunology, 1989
Substantial evidence indicates that airway hyperresponsiveness in asthma is associated with the inflammatory response directed toward the airway epithelium and submucosa. Endogenously released spasmogenic mediators interacting with smooth muscle have a greater effect on hyperresponsive than on normal airways.
S T, Holgate, J P, Finnerty
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Substantial evidence indicates that airway hyperresponsiveness in asthma is associated with the inflammatory response directed toward the airway epithelium and submucosa. Endogenously released spasmogenic mediators interacting with smooth muscle have a greater effect on hyperresponsive than on normal airways.
S T, Holgate, J P, Finnerty
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2015
Histamine is one of the best-characterized pruritogens in humans. It is known to play a role in pruritus associated with urticaria as well as ocular and nasal allergic reactions. Histamine mediates its effect via four receptors. Antihistamines that block the activation of the histamine H₁receptor, H₁R, have been shown to be effective therapeutics for ...
Robin L, Thurmond +3 more
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Histamine is one of the best-characterized pruritogens in humans. It is known to play a role in pruritus associated with urticaria as well as ocular and nasal allergic reactions. Histamine mediates its effect via four receptors. Antihistamines that block the activation of the histamine H₁receptor, H₁R, have been shown to be effective therapeutics for ...
Robin L, Thurmond +3 more
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Journal of the American Medical Association, 1947
Any medicament, no matter how valuable, may do great harm if it is employed indiscriminately. The fame of the new antihistaminic drugs has become so widespread, indeed, that they are often prescribed merely to satisfy the patient's curiosity. A critical inventory of their value is therefore indicated.
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Any medicament, no matter how valuable, may do great harm if it is employed indiscriminately. The fame of the new antihistaminic drugs has become so widespread, indeed, that they are often prescribed merely to satisfy the patient's curiosity. A critical inventory of their value is therefore indicated.
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Pharmacology of antihistamines
Journal of Allergy and Clinical Immunology, 1990Unlike the classic antihistamines, the new H1-receptor antagonists do not block cholinergic or central H1 receptors and thus do not produce the side effects, such as sedation, impaired psychomotor performance, and excessive mucosal drying, that are commonly associated with the older agents. Important pharmacokinetic and pharmacodynamic differences that
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Clinical & Experimental Allergy, 1999
Urticaria is one of the most common and, in its chronic course, excruciating dermato‐allergic diseases. Apart from the dermatological diagnosis, the identification and evaluation of causal triggering factors is of utmost importance. Here a ‘three‐step guideline’ (according to Ring and Przybilla) has gained acceptance, ranging from a general basic ...
J, Ring, K, Brockow, M, Ollert, R, Engst
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Urticaria is one of the most common and, in its chronic course, excruciating dermato‐allergic diseases. Apart from the dermatological diagnosis, the identification and evaluation of causal triggering factors is of utmost importance. Here a ‘three‐step guideline’ (according to Ring and Przybilla) has gained acceptance, ranging from a general basic ...
J, Ring, K, Brockow, M, Ollert, R, Engst
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The Lancet, 1983
With careful use of antihistamines central effects may be minimised or even largely avoided while adequate peripheral antihistaminic activity is preserved. Tolerance to central effects may develop quickly with some drugs, so that sedation is no longer troublesome after a few days.
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With careful use of antihistamines central effects may be minimised or even largely avoided while adequate peripheral antihistaminic activity is preserved. Tolerance to central effects may develop quickly with some drugs, so that sedation is no longer troublesome after a few days.
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Acta Physiologica Scandinavica, 1949
Summary.Cats were treated with doses of legation intravenously that suppressed the blood pressure action of moderate histamine doses. The responses of respiration to inhalation of gas mixtures poor in oxygen or rich in carom dioxide were undiminished.
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Summary.Cats were treated with doses of legation intravenously that suppressed the blood pressure action of moderate histamine doses. The responses of respiration to inhalation of gas mixtures poor in oxygen or rich in carom dioxide were undiminished.
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Tuberculosis and Antihistaminics
Diseases of the Chest, 19491) The present knowledge of antihistaminics, particularly the pharmacologic considerations are presented. 2) Tuberculous allergy and tuberculous anaphylaxis are presented as widely different mechanisms and carefully differentiated. 3) Neo-Antergan and phenergan (RP3277) were given for several months in a series of thirty patients with ...
T, MILLNER, A, HURST
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Annals of Otology, Rhinology & Laryngology, 1976
Antihistamines may be used to maximum benefit for the allergic patient if the physician adheres to four guidelines. These guidelines are based upon 1) an appreciation of certain structural and pharmacologic differences among antihistamines, and 2) an understanding of their mechanism of action.
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Antihistamines may be used to maximum benefit for the allergic patient if the physician adheres to four guidelines. These guidelines are based upon 1) an appreciation of certain structural and pharmacologic differences among antihistamines, and 2) an understanding of their mechanism of action.
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Journal of Clinical Pharmacy and Therapeutics, 2001
Histamine activates pain-transmitting nerve fibres, releases pain-related neuropeptides, and is painful when injected into the skin. Histamine agonists mimic these effects, suggesting that histamine plays a role in mediating the signal transduction of tissue damage or other painful stimulus.
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Histamine activates pain-transmitting nerve fibres, releases pain-related neuropeptides, and is painful when injected into the skin. Histamine agonists mimic these effects, suggesting that histamine plays a role in mediating the signal transduction of tissue damage or other painful stimulus.
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