Results 241 to 250 of about 308,964 (330)

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Protocol of the medygen-2024 study: assessment of antihypertensive medication use by sex in community pharmacies. [PDF]

open access: yesFarm Comunitarios
Alberto Armas D   +5 more
europepmc   +1 more source

Efficacy and Tolerability of Metyrapone in Mild Autonomous Cortisol Secretion: Real‐World Findings From Clinical Practice

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective Mild autonomous cortisol secretion (MACS) is associated with increased cardiometabolic risk factors including hypertension, type 2 diabetes and dyslipidaemia. By using evening doses of metyrapone, a short‐acting 11‐β hydroxylase inhibitor, it has been shown that it is possible to reset the abnormal circadian cortisol rhythm in MACS ...
Simon Berry   +3 more
wiley   +1 more source

Clinical and Radiographic Performance of Two Distinct Sandblasted, Large‐Grit, Acid‐Etched Implant Surfaces: A Split‐Mouth Randomized Clinical Trial

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Aim To compare the clinical performance of two sandblasted, large‐grit, acid‐etched implant surfaces regarding changes in radiographic marginal bone level (MBL) 12 months after loading. Materials and Methods In this randomized, split‐mouth, dual‐center clinical trial, each patient received one test (modified hydrophilic surface) implant and ...
Blanca Vílchez   +7 more
wiley   +1 more source

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

open access: yesClinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet   +3 more
wiley   +1 more source

Risk factors of adverse pregnancy outcomes in patients with immunoglobulin A nephropathy. [PDF]

open access: yesSci Rep
Asano Y   +6 more
europepmc   +1 more source

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