Results 131 to 140 of about 3,932,256 (404)

Trends in Antihypertensive Drug Use in Spanish Primary Health Care (1990- 2012)

, 2015
Objective: This study aimed to describe the use of antihypertensive in Extremadura (Spain) from 1990 to 2012 and its economic impact. Method: Information on antihypertensive drug (ATC C02, C03, C07, C08, C09) utilization was obtained from the community ...
M. Cáceres, P. Moyano, H. Fariñas, J. Cobaleda, A. Pijierro, P. Dorado, A. Llerena   +6 more
semanticscholar   +1 more source

Cytotoxic Activity of Opopanax hispidus (Friv.) Griseb.: Characterization of a New Chalcone‐type Compound

Chemistry &Biodiversity, EarlyView.
ABSTRACT The present study aimed to investigate cytotoxic compounds of Opopanax hispidus (Friv.) Griseb. through in vitro, in silico, and phytochemical analyses. The cytotoxic activity of O. hispidus was evaluated against four different cancer cell lines – lung (A549), breast (MCF‐7), liver (HepG2), and cervix (HeLa) – as well as one healthy cell line (
Kevser Taban, İpek Süntar, Perihan Gürbüz, Esra Emerce, Osman Tugay, Şengül Dilem Doğan, Beyza Hamur, Ahmet Ceyhan Gören   +7 more
wiley   +1 more source

Efficacy, safety and Cardiovascular Disease Risk Lowering Ability of ACE Inhibitors, β-Blockers and Combination Antihypertensive Drug Regimes in Iraq

Iraqi Journal of Pharmaceutical Sciences, 2017
Hypertension is a major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular diseases.
Dlveen M. Sulaiman, Kassim J.Al-Shamma, Ansam N.Al-Hassani   +2 more
doaj  

Endothelium‐Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca2+ Channels

Chemistry &Biodiversity, EarlyView.
Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo, Rita de Cássia Vilhena da Silva, Valdir Cechinel Filho, Priscila de Souza   +3 more
wiley   +1 more source

Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR) [PDF]

, 2009
<p><b>Background and Purpose:</b> The optimal management of blood pressure (BP) in acute stroke remains unclear. For ischemic stroke treated with intravenous thrombolysis, current guidelines suggest pharmacological intervention if ...
Ahmed, N., Ford, G.A., Kaste, M., Lees, K.R., Toni, D.   +4 more
core   +1 more source

I Brazilian Position Paper on Antihypertensive Drug Combination

Arquivos Brasileiros de Cardiologia, 2014
Arterial hypertension (AH) is a highly prevalent disease, and is a major cardiovascular (CV) risk factor1; therefore, achieving blood pressure (BP) control goals as soon as possible is paramount to reduce that risk2.
R. Póvoa, W. Barroso, A. Brandão, P. Jardim, Oswaldo Barroso, O. Passarelli, J. Gemelli, A. Feitosa, T. Jardim, S. Carneiro, C. Amodeo, O. Moreira, A. Nogueira, Nelson Siqueira de Morais, Luiz César Nazário Scala, Carolina C. Gonzaga, Dilma de Souza, Annelise Machado Gomes de Paiva, M. B. Malachias, D. Mion, M. Mota-Gomes, E. Barbosa, M. G. de Sousa, H. Bianco, F. H. Fonseca, Marcio Kalil, R. D. Miranda, Carlos André Uehara, A. F. Sanjuliani   +28 more
semanticscholar   +1 more source

Thiocarbamoylimidates as Precursors of New 5‐Amino‐1,2,4‐Triazole and Oxadiazole Derivatives In Silico Prediction of Absorption, Distribution, Metabolism, and Excretion Parameters

ChemPlusChem, EarlyView.
1,2,4‐triazole and oxadiazole motifs are synthesized from thiocarbamoylimidates precursors, under mild conditions (40 °C) in the environmentally friendly water/ethanol reaction medium. The reaction is highly versatile and allows for the introduction of a wide variety of functional groups.
Oumaima Gatri, Thierry Roisnel, Marie Cordier, Vincent Dorcet, Mohamed Lotfi Efrit, Cédric Fischmeister   +5 more
wiley   +1 more source

Effects of drug price reduction and prescribing restrictions on expenditures and utilisation of antihypertensive drugs in Korea

BMJ Open, 2015
Objectives To evaluate the quantitative effects of the drug price reduction on pharmaceutical expenditures and the new guidelines to restrict prescribing on drug utilisation for antihypertensive drugs.
Ki-Bong Yoo, Sang Gyu Lee, Sohee Park, Tae Hyun Kim, Jeonghoon Ahn, Mee-Hyun Cho, E. Park   +6 more
semanticscholar   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source