Results 21 to 30 of about 88,910 (264)

Study on the Excretion of a New Antihypertensive Drug 221s (2,9) in Rats

Pharmaceuticals
Background/Objectives: The novel compound 221s (2,9), derived from danshensu and ACEI-active proline, exhibits antihypertensive effects (50/35 mmHg SBP/DBP reduction in SHRs) with potential cough mitigation.
Yunmei Chen, Kuan Yang, Shaojing Liu, Lili Yu, Rong Wang, Bei Qin   +5 more
doaj   +1 more source

Toxicity Profiling and In Vivo Metabolism of Danshensu-Derived Novel Antihypertensive Candidate 221s (2,9)

Toxins
Compound 221s (2,9) is a novel antihypertensive drug candidate synthesized utilizing danshensu, borneol, and proline by using the strategy of combinatorial molecular chemistry.
Yunmei Chen, Kuan Yang, Lili Yu, Rong Wang, Shaojing Liu, Bei Qin   +5 more
doaj   +1 more source

EFFECT OF ANTIHYPERTENSIVE DRUGS ON QUALITY OF LIFE IN PATIENTS WITH ARTERIAL HYPERTENSION

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study effect of antihypertensive drugs on quality of life (QoL) of patients with stable arterial hypertension (HT).Material and methods. Results of some studies with similar design involving totally 170 patients with HT, aged 57,2±8,8 y.o., were ...
G. F. Andreeva, A. D. Deev, V. M. Gorbunov   +2 more
doaj   +3 more sources

Prescription pattern of antihypertensive drugs in Family Practice Clinics at Jordan University Hospital

Medicine Science, 2013
The present study represents the current prescribing trend for antihypertensive drugs in family medicine clinics at Jordan University Hospital in Jordan. The study sample involved 416 male and female hypertensive Jordanian patients.
Essam Al-Drabah, Yacoub Irshaid, Nada Yasein, Suheil Zmeili   +3 more
doaj   +1 more source

Antihypertensive Drug Use Pattern in a Tertiary Care Hospital of Western Region of Nepal: A Cross-Sectional Study

Journal of Lumbini Medical College, 2023
Introduction: Assessing antihypertensive drug use pattern always plays an important role to mitigate the burden of hypertension and also helps doctors to prescribe the drugs rationally.
Naresh Karki, Kamal Kandel, Pravin Prasad, Jeevan Khanal   +3 more
doaj   +1 more source

紫苏籽油的抗衰老作用及机制探究 Anti-aging effect and mechanisms of perilla seed oil

Zhongguo youzhi
旨在为紫苏籽油的开发利用提供理论依据，以D-半乳糖（500 mg/kg）在小鼠颈背部皮下连续注射4周建立小鼠衰老模型后，将小鼠随机分为模型对照组（生理盐水）、阳性对照组（维生素C 200 mg/kg）和紫苏籽油高（5 mL/kg）、中（2.5 mL/kg）、低（1.25 mL/kg）剂量组，连续灌胃4周，记录小鼠体质量及行为变化，通过转棒法和金属网法检测小鼠的协调运动能力，测定小鼠主要脏器（脑、胸腺、脾脏）指数以及小鼠血清和脑组织匀浆中谷胱甘肽过氧化物酶（GSH-Px）活力和丙二醛（MDA）含量 ...
王荣1,2,3，王娜娜1,2,3，杨宽1,2,3，刘自群1，秦蓓1,2,3 WANG Rong1,2,3，WANG Nana1,2,3， YANG Kuan1,2,3， LIU Ziqun1，QIN Bei1,2,3
doaj   +1 more source

Resistant and undertreated hypertension in patients with chronic kidney disease: data from the PATRIOTIC survey

Clinical and Experimental Hypertension, 2018
Background: Hypertension is prevalent in chronic kidney disease (CKD), but the control of hypertension is suboptimal. We reported the prevalence and characteristics of resistant and undertreated hypertension based on a nationwide survey aiming to improve
Ying Zheng, Li Tang, Xiangmei Chen, Guangyan Cai, Wenge Li, Zhaohui Ni, Wei Shi, Xiaoqiang Ding, Hongli Lin   +8 more
doaj   +1 more source

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source

Illuminating New Frontiers: Exploring the Photosensitizing Potential of Passiflora Species in Combating Methicillin‐Resistant Staphylococcus aureus (MRSA) and Their Infection in Senescent Mice

Advanced Biology, EarlyView.
This study investigates the photosensitizing potential of Passiflora cincinnata in Antimicrobial Photodynamic Therapy (aPDT) against skin infection caused by Methicillin‐resistant Staphylococcus aureus (MRSA) in a senescent murine model. The P. cincinnata exhibits antimicrobial activity, with reduced bacterial load, lower leukocyte infiltration, and ...
Caroline Vieira Gonçalves, Maria Poliana Leite Galantini, Igor Pereira Ribeiro Muniz, Paulo Henrique Bispo Lima, Israel Souza Ribeiro, Maria Eduarda Santos de Oliveira, Caio Oliveira Lopes de Magalhães, Maria Elisa Santos Flores, Samara Lopes de Oliveira, Catarina Silva Guimarães, Paulinne Moreira Lima, Luísa Carregosa Santos, Daiana Silva Lopes, Juliano Geraldo Amaral, Robson Amaro Augusto da Silva   +14 more
wiley   +1 more source

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source