Results 311 to 320 of about 92,770 (362)
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Dermatologic Therapy, 2001
Antimalarial medications have become the parenteral drugs of choice for treating the cutaneous manifestations of lupus erythematosus. The immune-modulating activity of these agents makes them useful in a variety of other dermatoses. With prudent dosage and monitoring, these agents can be used safely and effectively in the treatment and management of ...
M J, Van Beek, W W, Piette
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Antimalarial medications have become the parenteral drugs of choice for treating the cutaneous manifestations of lupus erythematosus. The immune-modulating activity of these agents makes them useful in a variety of other dermatoses. With prudent dosage and monitoring, these agents can be used safely and effectively in the treatment and management of ...
M J, Van Beek, W W, Piette
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The Lancet, 2004
Multidrug resistance has rendered monotherapy for malaria useless in most parts of the world, and has also compromised the usefulness of many of the available combination chemotherapies. New antimalarial regimens are, therefore, urgently needed. We review the various antimalarial combinations that can be used to treat otherwise drug-resistant disease ...
Peter Gottfried, Kremsner +1 more
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Multidrug resistance has rendered monotherapy for malaria useless in most parts of the world, and has also compromised the usefulness of many of the available combination chemotherapies. New antimalarial regimens are, therefore, urgently needed. We review the various antimalarial combinations that can be used to treat otherwise drug-resistant disease ...
Peter Gottfried, Kremsner +1 more
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Arthritis care & research, 2019
To determine whether offspring from mothers with systemic lupus erythematosus (SLE), exposed in utero to antimalarials, have an increased risk of ocular anomalies during childhood versus unexposed SLE offspring.
R. Gaffar +4 more
semanticscholar +1 more source
To determine whether offspring from mothers with systemic lupus erythematosus (SLE), exposed in utero to antimalarials, have an increased risk of ocular anomalies during childhood versus unexposed SLE offspring.
R. Gaffar +4 more
semanticscholar +1 more source
Journal of the American Academy of Dermatology, 1981
The antimalarials, chloroquine, hydroxychloroquine, and quinacrine, are used primarily for malaria; but they can be beneficial for cutaneous lupus erythematosus (LE), polymorphous light eruption, solar urticaria, and porphyria cutanea tarda. Antimalarials bind to deoxyribonucleic acid (DNA) which prevents DNA and ribonucleic acid (RNA) polymerase ...
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The antimalarials, chloroquine, hydroxychloroquine, and quinacrine, are used primarily for malaria; but they can be beneficial for cutaneous lupus erythematosus (LE), polymorphous light eruption, solar urticaria, and porphyria cutanea tarda. Antimalarials bind to deoxyribonucleic acid (DNA) which prevents DNA and ribonucleic acid (RNA) polymerase ...
openaire +2 more sources
Drug Discovery Today, 2005
Analysis of the trends in antimalarial research depicts a slow growth in launched products since 1995. However, 2002 saw the completion, after ten years, of the malarial genome project and an upsurge in products entering active development can be seen at the end of this period.
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Analysis of the trends in antimalarial research depicts a slow growth in launched products since 1995. However, 2002 saw the completion, after ten years, of the malarial genome project and an upsurge in products entering active development can be seen at the end of this period.
openaire +2 more sources
Current Opinion in Pharmacology, 2018
Over the past decade, new high-throughput phenotypic assays with malaria parasites have been developed, and these were used to screen millions of compounds. This effort, as well as improving older chemical scaffolds and optimising compounds against both known and new drug targets has resulted in the discovery of exciting new pipeline drug candidates ...
Rob, Hooft van Huijsduijnen +1 more
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Over the past decade, new high-throughput phenotypic assays with malaria parasites have been developed, and these were used to screen millions of compounds. This effort, as well as improving older chemical scaffolds and optimising compounds against both known and new drug targets has resulted in the discovery of exciting new pipeline drug candidates ...
Rob, Hooft van Huijsduijnen +1 more
openaire +2 more sources
[Antimalarial drug resistance].
Medecine et maladies infectieuses, 2006Drug resistant malaria is mostly due to Plasmodium falciparum, the highly prevalent species in tropical Africa, Amazon, and Southeast Asia. P. falciparum is responsible for severe involvement of fever or anemia causing more than a million deaths per year.
Le Bras, J., Musset, L., Clain, J.
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