Results 311 to 320 of about 90,085 (338)

Arteether, a new antimalarial drug: synthesis and antimalarial properties

Journal of Medicinal Chemistry, 1988
Arteether (6) has been prepared from dihydroquinghaosu (3) by etherification with ethanol in the presence of Lewis acid and separated from its chromatographically slower moving alpha-dihydroqinghaosu ethyl ether (7). The absolute stereochemistry at C-12 has been determined by 1H NMR data (J11,12, NOESY).
Arnold Brossi, L. Dominguez Gerpe, J. L. Flippen-Anderson, Herman J. C. Yeh, B. Venugopalan, P. Buchs, X. D. Luo, W. Peters, Wilbur K. Milhous   +8 more
openaire   +3 more sources

Antimalarial therapies

Drug Discovery Today, 2005
Analysis of the trends in antimalarial research depicts a slow growth in launched products since 1995. However, 2002 saw the completion, after ten years, of the malarial genome project and an upsurge in products entering active development can be seen at the end of this period.
openaire   +2 more sources

ChemInform Abstract: ANTIMALARIALS. 8. SYNTHESIS OF AMINO ETHERS AS CANDIDATE ANTIMALARIALS

Chemischer Informationsdienst, 1976
AbstractAus den Isobutyrophenonen (I) entstehen die Bromverbindungen (II), die über die Epoxide (III) zu den Aminoketonen (IV) führen.
John Menke, M. P. Lamontagne, M. S. Ao, Anica Markovac   +3 more
openaire   +4 more sources

Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.

Infectious Diseases - Drug Targets, 2014
The isolation of artemisinin from the traditional medicinal herb qīng hāo (Artemisia annua), its characterization as a peroxide and preparation of the derivatives dihydroartemisinin, artemether and artesunate in the 1970s and 1980s by Chinese scientists ...
R. Haynes, Kwan‐Wing Cheu, D. N'Da, P. Coghi, D. Monti   +4 more
semanticscholar   +1 more source

Plasmodium falciparum M1-aminopeptidase: a promising target for the development of antimalarials.

Current Drug Targets, 2014
Malaria is a devastating human parasitic disease that receives enhanced attention due to the emergence of resistance to traditional drugs. Thus, the search for new molecular targets is a major goal.
Jorge González-Bacerio, R. Fando, Alberto del Monte-Martínez, J. Charli, M. Chávez   +4 more
semanticscholar   +1 more source

Antimalarials in the Treatment of Schistosomiasis

Current Pharmaceutical Design, 2012
With just one drug used for individual patient management and community-based morbidity control, the treatment, control, and eventual elimination of schistosomiasis is vulnerable should resistance to praziquantel emerge and spread. The discovery and development of novel chemical entities that exhibit antischistosomal properties, and the repurposing of ...
Keiser, Jennifer, Utzinger, Jurg
openaire   +4 more sources

Antimalarial activity of cedronin

Journal of Ethnopharmacology, 1994
Cedronin was isolated from Simaba cedron Planchon (Simaroubaceae), a species popularly believed in South America to have antimalarial properties. It was examined for in vitro and in vivo antimalarial activities and for cytotoxicity against KB cells. Experimental results showed that cedronin was active against chloroquine-sensitive and resistant strain,
Eric Deharo, Michel Sauvain, M. Gasquet, P. Timon David, C. Moretti, C. Jardel   +5 more
openaire   +3 more sources

Dried blood spots in bioanalysis of antimalarials: relevance and challenges in quantitative assessment of antimalarial drugs.

Bioanalysis, 2013
Malaria is the leading parasitic disease in emerging countries. Therapeutic drug monitoring of antimalarial drugs is becoming increasingly important due to their spreading resistance.
Isha Taneja, Madhuri Erukala, K. S. Raju, S. Singh, Wahajuddin   +4 more
semanticscholar   +1 more source

Antimalarial Drugs

Drugs, 1987
Over the last decade, chloroquine-resistant falciparum malaria has spread to other areas from its original foci in Southeast Asia and South America. Additionally, new knowledge about the life-cycle of the malaria parasite, and about the pharmacokinetic properties of antimalarial drugs, has emerged.
openaire   +3 more sources

Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials

2014
This chapter provides details of studies that describe drug interactions in which antimalarial drugs affect the pharmacokinetics of various co-administered antimalarial drugs. These antimalarials include amodiaquine, artemether, artemisinin, artesunate, atovaquone, chloroquine, dapsone, mefloquine, primaquine, proguanil, pyrimethamine, quinidine ...
Tony K. L. Kiang, Kyle John Wilby, Mary H H Ensom   +2 more
openaire   +2 more sources