Results 71 to 80 of about 16,033 (175)

Pseudophakic macular edema in a steroid responder treated successfully with intravitreal methotrexate: A case report

Indian Journal of Ophthalmology. Case Reports
Pseudophakic macular edema (PME) is typically treated with nonsteroidal anti-inflammatory drugs (NSAIDs) initially, followed by steroids. Treatment with steroids becomes challenging in steroid responders. We report a case of PME treated with intravitreal
Simran, Suresh Ramchandani, Shubhangi Mahesh, Fatema Lokhandwala   +3 more
doaj   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

Silver nanoparticles induce reactive oxygen species-mediated cell cycle delay and synergistic cytotoxicity with 3-bromopyruvate in Candida albicans, but not in Saccharomyces cerevisiae

International Journal of Nanomedicine, 2019
Bokyoung Lee,1,2 Mi Jin Lee,1 Su Jin Yun,1,2 Kyongmin Kim,1,2 In-Hong Choi,3 Sun Park1,21Department of Microbiology, Ajou University School of Medicine, Suwon, 442-749, Republic of Korea; 2Department of Biomedical Sciences, The Graduate School,
Lee B, Lee MJ, Yun SJ, Kim K, Choi IH, Park S   +5 more
doaj  

Nosocomial Infections in Hospitalised Haematological Patients: A Retrospective Observational Record‐Based Study

Nursing Open, Volume 13, Issue 11, November 2026.
ABSTRACT Aim To estimate the prevalence of nosocomial infections in haematological patients hospitalised between 2020 and 2022, identify associated risk factors, and describe antibiotic use before and during hospitalisation. Background Studies integrating clinical, environmental, microbiological and pharmacological data in this population remain ...
Laura Cabrera‐Jaime, Sandra Cabrera‐Jaime, Maria Feijoo‐Cid, Enric Limón   +3 more
wiley   +1 more source

Serial growth plate monitoring in a 3‐month‐old Labrador retriever receiving vinblastine chemotherapy

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 3‐month‐old, male, entire Labrador retriever was presented for evaluation of a congenital mast cell tumour of the right pinna. Pinnectomy and regional lymphadenectomy confirmed a high‐grade mast cell tumour with nodal pre‐metastasis. Eight vinblastine chemotherapy treatments were administered over 12 weeks.
Paige A. A. Brown, Kate M. Sippel, Alison Masyr   +2 more
wiley   +1 more source

Riboflavin Metabolism Links Metabolic State to Biofilm Development, Cell‐Envelope Homeostasis, and Antimicrobial Susceptibility in Mycobacterium tuberculosis

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
Using functional genomics, CRISPRi‐mediated perturbation and targeted overexpression, coupled with metabolic perturbation, phenotypic characterization and systems‐level analyses, we uncover riboflavin metabolism as a signalling axis linking cellular metabolism to biofilm‐associated community behaviour in Mycobacterium tuberculosis.
Anannya Dhanwal, Vaishnavi Tripathi, Saptarshi Sengupta, Linus Augustin, Manish Bansal, Sheetal Gandotra, Nisheeth Agarwal, Ruchi Jain Dey   +7 more
wiley   +1 more source

A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation

Journal of Analytical Methods in Chemistry, 2019
The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan ...
Liliya K. Shpigun, Elena Yu. Andryukhina
doaj   +1 more source

The efficacy and safety of reducing intraocular pressure to single‐digit levels in Normal‐tension glaucoma: A systematic review and meta‐analysis

Acta Ophthalmologica, Volume 104, Issue 7, Page 720-730, November 2026.
Abstract Purpose This systematic review and meta‐analysis aim to evaluate the efficacy and safety of further lowering intraocular pressure (IOP) to single‐digit levels in treated patients with progressive normal‐tension glaucoma (NTG). Methods A literature search was conducted in MEDLINE (via PubMed), Scopus and Web of Science. We selected studies that
Beatriz Araújo‐Azevedo, Renato Ferreira‐da‐Silva, João Barbosa‐Breda   +2 more
wiley   +1 more source

Leftover mitomycin-c sponge causing blebitis

Indian Journal of Ophthalmology, 2019
Trabeculectomy is the commonest surgical intervention performed worldwide for the treatment of open-angle glaucoma. However, the use of antimetabolites during trabeculectomy has been associated with various bleb related complications.
Mayuri Khamar, Deepak Bhojwani, Priyanka Patel, Abhay Vasavada   +3 more
doaj   +1 more source

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Khalid J.H. Alzahrani, Juma A.M. Ali, Anthonius A. Eze, Wan Limm Looi, Daniel N.A. Tagoe, Darren J. Creek, Michael P. Barrett, Harry P. de Koning   +7 more
doaj   +1 more source