Results 331 to 340 of about 2,068,221 (381)

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source

Wrong diagnosis - Wrong antimicrobials: Rise in antimicrobial resistance in developing countries. [PDF]

IDCases
Panda PK.
europepmc   +1 more source

Colonic Submucosa Targeted Delivery of Probiotic and Rhein for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
A novel orally drug‐probiotic co‐delivery system designated as Rh‐YBS for UC treatment, which highlights three innovations: (i) YPs involves colonic submucosa delivery via M cells; (ii) Rh (drug) promotes the colonization and growth of BS (probiotic) in the colon.
Lingqiang Li, Linxin Dai, Meisi Lin, Shuang He, Hongye Du, Dasheng Lin, Yanbin Wang, Fenglian Zhang, Sian Tao, Xiaoluo Sun, Xinggui Huang, Haihui Liu, Qian Wang, Lingling He, Kunhe Wu, Jieshu You, Minyue Zhang, Chaomei Fu, He Tu, Naijing Ye, Jibin Liu, Fei Gao   +21 more
wiley   +1 more source

Correction to: Pandemic human-associated extended-spectrum β-lactamase-producing Escherichia coli lineages of ST38, ST131 and ST141 identified in Viennese dogs. [PDF]

J Antimicrob Chemother
europepmc   +1 more source

Evaluation of FASTinov for rapid antimicrobial susceptibility testing in Pseudomonas aeruginosa. [PDF]

Sci Rep
Cintora-Mairal C, de la Rosa JMO, Pina-Vaz C, Martín-Gutiérrez G, Lepe JA.   +4 more
europepmc   +1 more source

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

Advanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou   +15 more
wiley   +1 more source

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, EarlyView.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

Synthesis and Biological Evaluation of Acridone Derivatives for Antimicrobial and Antifungal Applications. [PDF]

J Exp Pharmacol
Al-Shami AS, Alkadsi J.
europepmc   +1 more source

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Innovations in Edible Packaging Films, Coatings, and Antimicrobial Agents for Applications in Food Industry. [PDF]

Compr Rev Food Sci Food Saf
Kumar L, Tyagi P, Lucia L, Pal L.
europepmc   +1 more source