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Unifying the classification of antimicrobial peptides in the antimicrobial peptide database
2022Natural products offer an important avenue to novel therapeutics against drug-resistant bacteria, viruses, fungi, parasites, and cancer. However, there are numerous hurdles and challenges in discovering such molecules, including antimicrobial peptides (AMPs).
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Antimicrobial peptides and the skin
Expert Opinion on Biological Therapy, 2004In recent years, hundreds of naturally occurring peptide antibiotics have been discovered based on their ability to inhibit the growth of microbial pathogens. These antimicrobial peptides (AMPs) participate in the innate immune response by providing a rapid first-line defence against infection.
Antoanella, Bardan +2 more
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Antimicrobial Peptides in the Brain
Archivum Immunologiae et Therapiae Experimentalis, 2010Antimicrobial peptides (AMPs) are an evolutionarily conserved component of the innate immune system of many species. The brain is an immunologically privileged organ but can produce a robust immune response against pathogens and cell debris, promoting rapid and efficient clearance.
Su, Yanhua +2 more
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Surgical Infections, 2018
Abstract Background: Bacterial resistance to available antibiotics has resulted in enhanced efforts at antibiotic stewardship but also has led to investigation into alternative methods for managing surgical infections.
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Abstract Background: Bacterial resistance to available antibiotics has resulted in enhanced efforts at antibiotic stewardship but also has led to investigation into alternative methods for managing surgical infections.
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Branched antimicrobial peptides
Russian Journal of Bioorganic Chemistry, 2007Branched peptides E(RLAR)2, E[E(RLAR)2]2, E(KLAR)2, and E[E(KLAR)2]2 were synthesized on the basis of tetrapeptides RLAR and KLAR and glutamic acid bis(pentafluorophenyl) ester. Their minimal antimicrobial concentrations were shown to decrease along with increase in branching, achieving 12 microM for Escherichia coli cells, which is comparable to ...
A Iu, Khrushchev +3 more
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Recent Patents on Anti-Infective Drug Discovery, 2018
After the era of serendipitous discovery of penicillin and outburst in the discovery and development of highly efficient antibiotics, a surge in resistance against the target specific drugs was observed, primarily due to a combination of selective pressure of antibiotics use and spontaneous mutations.
Komal, Sharma +3 more
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After the era of serendipitous discovery of penicillin and outburst in the discovery and development of highly efficient antibiotics, a surge in resistance against the target specific drugs was observed, primarily due to a combination of selective pressure of antibiotics use and spontaneous mutations.
Komal, Sharma +3 more
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Antimicrobial Peptides: An Introduction
2016The "golden era" of antibiotic discovery has long passed, but the need for new antibiotics has never been greater due to the emerging threat of antibiotic resistance. This urgency to develop new antibiotics has motivated researchers to find new methods to combat pathogenic microorganisms resulting in a surge of research focused around antimicrobial ...
Evan F, Haney +2 more
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Antimicrobial Peptides in the Airway
2006The airway provides numerous defense mechanisms to prevent microbial colonization by the large numbers of bacteria and viruses present in ambient air. An important component of this defense is the antimicrobial peptides and proteins present in the airway surface fluid (ASF), the mucin-rich fluid covering the respiratory epithelium. These include larger
D M, Laube +4 more
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Antimicrobial peptides of vertebrates
Current Opinion in Immunology, 1998The past year brought several discoveries that focused attention on antimicrobial peptides on epithelial surfaces. The malfunction of these substances was implicated as a cause of airway infections in cystic fibrosis. Other highlights included new insights into the relative selectivity of antimicrobial peptides for microbial membranes, their primary ...
T, Ganz, R I, Lehrer
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Antimicrobial peptides in plants.
2010AbstractThis chapter provides an overview of plant antimicrobial peptides. It mainly focuses on one particular class of plant defence peptides, namely the cyclotides, which have been discovered over the last decade in plants from the Rubiaceae, Violaceae and Cucurbitaceae families.
Kaas, Quentin +3 more
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