Results 201 to 210 of about 404,460 (263)

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Antimicrobial Resistance: How Can We Overcome the Problem? [PDF]

Antibiotics (Basel)
Sora VM, Wallet C, Meroni G, Loustau T, Rohr O, Zecconi A, Schwartz C.   +6 more
europepmc   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Italy's progress towards the objectives of the national action plan to combat antimicrobial resistance. [PDF]

PLoS One
Vicentini C, di Giacomo S, Bresciano L, Fadda G, Grossi A, D'Ancona F, Zotti CM, SPiNCAR working group.   +7 more
europepmc   +1 more source

Enhanced Antibacterial Properties of Lyotropic Liquid Crystalline Nanoparticles via Curvature Modulation

Advanced Science, EarlyView.
Lipid nanostructured particles with increasing negative Gaussian curvature progress from vesicles to P‐cubosomes and D‐cubosomes. This curvature hierarchy enhances interaction with bacterial membranes, promotes membrane remodeling and leakage, and potentiates daptomycin activity against MRSA.
Xiangfeng Lai, Shuhong Wang, Chenguang Ding, Xenia Kostoulias, Anton P. Le Brun, Hsien‐Yi Hsu, Jhih‐Hang Jiang, Yajun Wang, Richard A. Strugnell, Anton Y. Peleg, Hsin‐Hui Shen   +10 more
wiley   +1 more source

Erratum: Enhancing antimicrobial resistance (AMR) surveillance data use in Uganda - ERRATUM. [PDF]

Antimicrob Steward Healthc Epidemiol
Chukwuma U, Mayito J, Twemanye V, Namusoosa R, Kakyakumaiso D, Otita M, Tabajjwa D, Guma C, Brett-Major D, Walmema R.   +9 more
europepmc   +1 more source

Antimicrobial Resistance and Clinical Outcomes of Uropathogenic Enterococcal Infections in Hospitalised Patients. [PDF]

Cureus
Korochikar SP, Mane PM, Patil SR, Shelke YP, Patil SN, Korochikar PV.   +5 more
europepmc   +1 more source

Antimicrobial resistance and physician prescribing of antibiotics in Alberta: a qualitative exploration. [PDF]

BMC Health Serv Res
Kain N, Hurava I, Gilani F, Smilski K, Hamayeli-Mehrabani H, Hernandez-Ceron N, Ashworth N, Lindeman C.   +7 more
europepmc   +1 more source