Results 111 to 120 of about 42,192 (254)

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Tracking progress on antimicrobial resistance by the quadripartite country self-assessment survey (TrACSS) in G7 countries, 2017–2023: opportunities and gaps

Pharmacological Research
Antimicrobial resistance (AMR) poses serious challenges to the healthcare systems worldwide. Multiple factors and activities contribute to the development and spread of antimicrobial-resistant microorganisms.
Michela Sabbatucci, Diane Ashiru-Oredope, Laura Barbier, Elisa Bohin, Sabine Bou-Antoun, Colin Brown, Alexandra Clarici, Claire Fuentes, Takahiro Goto, Francesco Maraglino, Julien Morin, Ines Rönnefahrt, Andrea Sanwidi, Carry Triggs-Hodge, Antonio Vitiello, Andrea Zovi, Marcello Gelormini, Danilo Lo Fo Wong   +17 more
doaj   +1 more source

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

New approaches to combat Antimicrobial Resistance (AMR)?

Antimicrobial resistance (AMR) is a complex global health challenge arising from improper antibiotic usage in both human and animal domains, including the misguided application of antibiotics as growth promoters in animals. A deficiency in public understanding of antibiotics among diverse stakeholders further compounds this issue.
Louis Dillac, Werner Christie, Danielle van Dalen, Rio D. Praaning   +3 more
openaire   +1 more source

Simultaneous modification of Thermotoga maritima encapsulin subunits to produce multivalent nanoparticle vaccines for non‐typhoidal Salmonella enterica

The FEBS Journal, EarlyView.
This study investigates the modularity of encapsulin—a protein nanoparticle—by simultaneously inserting up to four distinct Salmonella epitopes within the encapsulin subunit. The encapsulin variants were transiently expressed in plants where they assembled into nanoparticles; however, their accumulation and stability varied depending on the ...
Carly A. Charron, Angelo Kaldis, Shabnam Shamriz, Moussa S. Diarra, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

Clinical Performance of Bioglass‐Enriched Resin Modified Glass Ionomer in Sealing Moderate Carious Lesions: An 18‐Month Split‐Mouth Clinical Trial

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Dental materials with the potential for caries progression prevention have been an attractive alternative to minimally invasive treatments. Objectives This randomized controlled split‐mouth clinical trial aimed to assess, after 18 months, the retention, restoration quality, and caries progression or arrestment of active moderate carious ...
Juliana Aguiar Costa Mesquita, Ana Carolina Soares Diniz, Mayenne Rabelo Araujo, Etevaldo Matos Maia Filho, Leily Macedo Firoozmand   +4 more
wiley   +1 more source

Can Artificial Intelligence Be Utilised to Develop Point‐of‐Care Endodontic Microbiological Technologies?

International Endodontic Journal, EarlyView.
ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley   +1 more source

Antimicrobial resistance with a focus on antibacterial, antifungal, antimalarial, and antiviral drugs resistance, its threat, global priority pathogens, prevention, and control strategies: a review

Therapeutic Advances in Infectious Disease
Antimicrobial resistance (AMR) poses a significant global health threat by diminishing the effectiveness of once-powerful antimicrobial agents, leading to higher rates of illness and death, along with escalating healthcare costs.
Wubetu Yihunie Belay, Melese Getachew, Bantayehu Addis Tegegne, Zigale Hibstu Teffera, Abebe Dagne, Tirsit Ketsela Zeleke, Samuel Agegnew Wondm, Rahel Belete Abebe, Abebaw Abie Gedif, Abebe Fenta, Getasew Yirdaw, Adane Tilahun, Yibeltal Aschale   +12 more
doaj   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Systemic Antibiotics in the Surgical Treatment of Peri‐Implantitis: Impact on the Salivary Microbiome

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To exploratorily compare the shifts in the salivary microbiome composition after administration of two combined systemic antibiotic regimens used in the surgical treatment of peri‐implantitis. Materials and Methods A subset of 27 patients treated surgically for peri‐implantitis with an adjunctive 7‐day course of systemic antibiotics were ...
Caroline Riben Grundström, Bodil Lund, Nagihan Bostanci, Angelika Silbereisen, Alexandra Pennhag, Ina Schuppe Koistinen, Yinghua Zha, Anastasios Damdimopoulos, Georgios N. Belibasakis, Margareta Hultin   +9 more
wiley   +1 more source