Results 1 to 10 of about 11,583 (90)

Pharmacogenomics of Antineoplastic Therapy in Children: Genetic Determinants of Toxicity and Efficacy [PDF]

Pharmaceutics
Over the past decades, remarkable progress in multimodal therapy has significantly improved survival outcomes for children with cancer. Yet, considerable variability in treatment response and toxicity persists, often driven by underlying genetic ...
Zaure Dushimova, Timur Saliev, Aigul Bazarbayeva, Gaukhar Nurzhanova, Ainura Baibadilova, Gulnara Abdilova, Ildar Fakhradiyev   +6 more
doaj   +2 more sources

Is Micronucleus Assay a Suitable Biomarker for Evaluating the Cancer Risk in Professionals Exposed to Antineoplastic Drugs? A Systematic Review. [PDF]

J Appl Toxicol
ABSTRACT The widespread use of antineoplastic drugs in cancer treatment has led to significant concerns regarding the potential health risks posed to healthcare professionals involved in the preparation, administration, and handling of these chemical compounds, including genotoxicity.
Pinto TG, da Silva Avanci L, de Aguiar GC, de Souza DV, Cury PR, Renno ACM, Ribeiro DA.   +6 more
europepmc   +2 more sources

Fertility preservation in women with sarcoma: A real-world experience. [PDF]

Int J Cancer
What's New? Sarcomas frequently affect adolescent girls and young women, but limited data exist on ovarian function following sarcoma treatment. This observational cohort study evaluated the feasibility, timing, and clinical relevance of fertility preservation in young women treated for high‐grade sarcomas or desmoid tumors.
Beinse G, Boudou-Rouquette P, de Percin S, Fortin A, Noel J, Kreps S, Sroussi J, Barraud-Lange V, Alexandre J, Goldwasser F, Tlemsani C, Poirot C.   +11 more
europepmc   +2 more sources

Comprehensive Analysis of Chemotherapeutic Agents That Induce Infectious Neutropenia

Pharmaceuticals, 2021
Chemotherapy-induced neutropenia (CIN) has been associated with a risk of infections and chemotherapy dose reductions and delays. The chemotherapy regimen remains one of the primary determinants of the risk of neutropenia, with some regimens being more ...
Mashiro Okunaka, Daisuke Kano, Reiko Matsui, Toshikatsu Kawasaki, Yoshihiro Uesawa   +4 more
doaj   +1 more source

Antineoplastics Encapsulated in Nanostructured Lipid Carriers

Molecules, 2021
Ideally, antineoplastic treatment aims to selectively eradicate cancer cells without causing systemic toxicity. A great number of antineoplastic agents (AAs) are available nowadays, with well-defined therapeutic protocols.
Gustavo Henrique Rodrigues da Silva, Ludmilla David de Moura, Fabíola Vieira de Carvalho, Gabriela Geronimo, Talita Cesarim Mendonça, Fernando Freitas de Lima, Eneida de Paula   +6 more
doaj   +1 more source

Antineoplastic Properties by Proapoptotic Mechanisms Induction of Inula viscosa and Its Sesquiterpene Lactones Tomentosin and Inuviscolide

Biomedicines, 2022
Cancer is a complex disease including approximately 200 different entities that can potentially affect all body tissues. Among the conventional treatments, radiotherapy and chemotherapy are most often applied to different types of cancers.
Rossana Migheli, Patrizia Virdis, Grazia Galleri, Caterina Arru, Giada Lostia, Donatella Coradduzza, Maria Rosaria Muroni, Giorgio Pintore, Luigi Podda, Claudio Fozza, Maria Rosaria De Miglio   +10 more
doaj   +1 more source

Electrolyte Disorders Induced by Antineoplastic Drugs

Frontiers in Oncology, 2020
The use of antineoplastic drugs has a central role in treatment of patients affected by cancer but is often associated with numerous electrolyte derangements which, in many cases, could represent life-threatening conditions.
Ignazio Verzicco, Giuseppe Regolisti, Federico Quaini, Pietro Bocchi, Irene Brusasco, Massimiliano Ferrari, Giovanni Passeri, Valentina Cannone, Pietro Coghi, Enrico Fiaccadori, Alessandro Vignali, Riccardo Volpi, Riccardo Volpi, Aderville Cabassi   +13 more
doaj   +1 more source

PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells

Frontiers in Physiology, 2019
PARP-1 inhibition has recently been employed in both mono- and combination therapies in various malignancies including melanoma with both promising and contradicting results reported.
Anna Maria Cseh, Anna Maria Cseh, Zsolt Fabian, Ruben Quintana-Cabrera, Ruben Quintana-Cabrera, Ruben Quintana-Cabrera, Aliz Szabo, Aliz Szabo, Krisztian Eros, Krisztian Eros, Krisztian Eros, Maria Eugenia Soriano, Maria Eugenia Soriano, Ferenc Gallyas, Ferenc Gallyas, Ferenc Gallyas, Luca Scorrano, Luca Scorrano, Balazs Sumegi, Balazs Sumegi, Balazs Sumegi   +20 more
doaj   +1 more source

Drug-induced QT interval prolongation in cancer patients

Oncology Reviews, 2011
Cancer patients are at an increased risk for QT interval prolongation and subsequent potentially fatal Torsade de pointes tachycardia due to the multiple drugs used for treatment of malignancies and the associated symptoms and complications.
Torben K. Becker, Sai-Ching J. Yeung
doaj   +1 more source

Efficiency of four solutions in removing 23 conventional antineoplastic drugs from contaminated surfaces.

PLoS ONE, 2020
BackgroundResidual contamination by intravenous conventional antineoplastic drugs (ICAD) is still a daily issue in hospital facilities. This study aimed to compare the efficiency (EffQ) of 4 different solutions to remove 23 widely used ICADs from ...
Nicolas Simon, Nicolas Guichard, Pascal Odou, Bertrand Decaudin, Pascal Bonnabry, Sandrine Fleury-Souverain   +5 more
doaj   +1 more source