Results 151 to 160 of about 152,699 (284)

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Substantial Increase in the Costs of Antineoplastic Agents in the USA from 2010 to 2021. [PDF]

Clinicoecon Outcomes Res
Althemery AU.
europepmc   +1 more source

First use of antineoplastic agents in women with breast cancer in the state of Rio de Janeiro, Brazil. [PDF]

Front Pharmacol, 2023
Dos Santos RLB, Osorio-de-Castro CGS, Sobreira-da-Silva MJ, Pepe VLE.   +3 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Ototoxicity Associated with Antineoplastic Agents in the Pediatric Population: An Evidence-Based Review of Auditory Monitoring Strategies and Contemporary Diagnostic Frameworks-Narrative Review. [PDF]

Diagnostics (Basel)
Wojno A, Cichy O, Wojno A, Dorobisz K, Pazdro-Zastawny K.   +4 more
europepmc   +1 more source

ACEI/ARB and beta-blocker therapies for preventing cardiotoxicity of antineoplastic agents in breast cancer: a systematic review and meta-analysis. [PDF]

Heart Fail Rev, 2023
Gao Y, Wang R, Jiang J, Hu Y, Li H, Wang Y.   +5 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Signals of interstitial lung disease with novel antineoplastic agents in ovarian cancer: a three-database disproportionality study. [PDF]

Front Pharmacol
Yang C, Song X, Sun H, Chen M, Chen X, Liu C, Wang Z, Zhu X.   +7 more
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

PRELIMINARY CHARACTERIZATION OF EXPOSURES TO ANTINEOPLASTIC AGENTS IN A DRUG PREPARATION AREA (FLUOROURACIL, CYCLOPHOSPHAMIDE, HOSPITALS.

, 1983
PRELIMINARY CHARACTERIZATION OF EXPOSURES TO ANTINEOPLASTIC AGENTS IN A DRUG PREPARATION AREA (FLUOROURACIL, CYCLOPHOSPHAMIDE ...
ANNA MARIA DE WERK. NEAL (7987853)
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