Results 61 to 70 of about 1,706,856 (229)

Peritoneal regression grading score (PRGS): first evidence for independent predictive and prognostic significance

Pleura and Peritoneum, 2023
The peritoneal regression grading score (PRGS) is a four-tied pathologic score measuring tumor regression in biopsies from patients with peritoneal metastasis (PM) receiving chemotherapy.
Baake Janina, Nadiradze Giorgi, Archid Rami, Königsrainer Alfred, Bösmüller Hans, Reymond Marc, Solass Wiebke   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Prevention and Management of Antineoplastic Extravasation Injury

, 2000
Goal The goal of this program is to inform the participant of practical ways to prevent, identify, and manage the extravasation of anti-neoplastic agents. Objectives At the completion of this program the participant will be able to: 1.
Linda S. Tyler, Shantel Mullin, M. Christina Beckwith   +2 more
core   +1 more source

Immunotherapies, Anti-Neoplastic Agents, and Wound Healing

Archives of Plastic Surgery
Background: For patients receiving immunotherapies and anti-neoplastic agents, understanding the implications of medication effects on wound healing is critical for surgical planning.
Katherine Kozlowski, Chloe Cottone, Julissa Molina-Vega, Sumun Khetpal, Alyssa D Reese, Joshua Sorrentino, Joshua Hwang, Olga Olevsky, Andrew Vardanian   +8 more
doaj   +1 more source

Taxanes: vesicants, irritants, or just irritating?

Therapeutic Advances in Medical Oncology, 2014
Several classes of antineoplastic agents are universally referred to as vesicants with ample supporting literature. However, the literature surrounding the taxanes is controversial.
Meagan S. Barbee, Taofeek K. Owonikoko, R. Donald Harvey   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

NIOSH list of antineoplastic and other hazardous drugs in healthcare settings 2016 [PDF]

Supersedes: NIOSH list of antineoplastic and other hazardous drugs in healthcare settings 2014 [DHHS publication ; no. (NIOSH) 2014-138].The National Institute for Occupational Safety and Health (NIOSH) Alert: Preventing Occupational Exposures to ...

core   +3 more sources

Assessment of the implementation of accelerated drug marketing registration procedures for antineoplastic and immunomodulating agents in China: based on 2016–2022 review data

Frontiers in Pharmacology
Objective:Since 2016, China has successively implemented Accelerated Drug Marketing Registration Procedures (ADMRPs) for drugs, including Breakthrough Therapy Drug (BTD), Conditional Approval (CA), and Priority Review and Approval (PRA), which have ...
Yipeng Lan, Xiaofeng Lin, Jialin Yu, Li Wang, Lihua Sun, Lihua Sun, Zhe Huang, Zhe Huang   +7 more
doaj   +1 more source