Results 91 to 100 of about 288,402 (222)
A Dual Approach for Positive T-S Fuzzy Controller Design and Its Application to Cancer Treatment Under Immunotherapy and Chemotherapy [PDF]
arXiv, 2019 This study proposes an effective positive control design strategy for cancer treatment by resorting to the combination of immunotherapy and chemotherapy. The treatment objective is to transfer the initial number of tumor cells and immune-competent cells from the malignant region into the region of benign growth where the immune system can inhibit tumor
arxiv
Microneedles at the Forefront of Next Generation Theranostics
Advanced Science, EarlyView.The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang +8 more
wiley +1 more source
BJUI Compass, Volume 4, Issue 1, Page 44-58, January 2023., 2023 Abstract Metformin, the first line pharmacotherapy for type 2 diabetes has demonstrated favourable effects in prostate cancer (PCa) across a range of studies evaluating PCa patient outcomes amongst metformin users. However, a lack of rigorously conducted prospective studies has stalled clinical use in this setting.
Nan Fang Wang +3 more
wiley +1 more source
Middle East Journal of Cancer, 2019 Background: Gastric cancer is one of the most common malignancies worldwide with a high case mortality rate. In metastatic gastric cancer, a proper combination of chemotherapy could increase the survival rate. The goal of this study is to evaluate the
Saeid Anvari +7 more
doaj
Advanced Science, EarlyView.Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He +6 more
wiley +1 more source
Optimizing chemoradiotherapy to target multi-site metastatic disease and tumor growth [PDF]
arXiv, 2016 The majority of cancer-related fatalities are due to metastatic disease. In chemoradiotherapy, chemotherapeutic agents are administered along with radiation to increase damage to the primary tumor and control systemic disease such as metastasis.
arxiv
Advanced Science, EarlyView.Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li +12 more
wiley +1 more source
Antiproliferative MCR peptides block physical interaction of insulin with retinoblastoma protein (RB) in human lung cancer cells [PDF]
arXiv, 2007 Fifteen years ago, a structural analysis of the hormone insulin and the retinoblastoma tumor suppressor protein (RB) revealed that they may physically interact with one another. Subsequently, an RB peptide corresponding to the proposed RB binding site for insulin was found to recognize full-length insulin in vitro.
arxiv
Machine Learning‐Enabled Drug‐Induced Toxicity Prediction
Advanced Science, EarlyView.Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai +5 more
wiley +1 more source
Advanced Science, EarlyView.A tumor‐adhesive chitosan‐derived immune agonist TACTIC is developed for strong and durable anti‐tumor immunity. The immune agonist exhibits multi‐targets and modulates both tumor cell immunogenicity and pro‐inflammatory responses in immune cells, thereby potentiating the therapeutic efficacy of clinical radiotherapy.
Huilan He +8 more
wiley +1 more source