Results 111 to 120 of about 180 (146)

ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling

Advanced Science, EarlyView.
In this study, ferroptosis in colorectal cancer cells is induced by FK866 through the NAD⁺/STAT3/GPX4 pathway. To minimize systemic toxicity, a reactive oxygen species (ROS)‐responsive hydrogel is developed to co‐deliver FK866 and C188‐9, resulting in synergistic and localized antitumor effects.
Chenyang Ye, Mi Mi, Saimeng Shi, Lina Qi, Shanshan Weng, Lu Wang, Yier Lu, Chao Chen, Yinuo Tan, Mengyuan Yang, Cheng Guo, Rui Bai, Xuefeng Fang, Ji Wang, Ying Yuan   +14 more
wiley   +1 more source

A Novel Class of Multi‐substituted Diaryl Scaffold Derivatives Inhibit Glioblastoma Progression by Targeting CD155

Advanced Science, EarlyView.
Structural modification of clofoctol yielded a novel blood‐brain barrier‐permeable compound, B7, featuring a multi‐substituted diaryl scaffold. B7 demonstrates potent anti‐glioblastoma activity by suppressing glioblastoma stem cells proliferation, migration, and invasion through interactions with five key residues of poliovirus receptor cell adhesion ...
Yong‐jian Wang, Ting Sun, Si‐tu Xue, Zhong‐di Cai, Hong Yi, Miao Lv, Shi‐bo Kou, Rui Liu, Xiao‐zhong Peng, Zhuo‐rong Li   +9 more
wiley   +1 more source

Prognostic factors for patients with esophageal cancer who achieve pathological complete response in the primary tumor after upfront chemotherapy or chemoradiotherapy

Annals of Gastroenterological Surgery, EarlyView.
Male gender and pathological lymph node metastasis are independent poor prognostic factors in patients with esophageal cancer who receive upfront treatment followed by surgery and achieved pathological complete response of the primary tumor. Among patients without pathological lymph node metastasis, the upfront chemotherapy group showed significantly ...
Masaaki Motoori, Koji Tanaka, Hiroshi Miyata, Makoto Yamasaki, Osamu Shiraishi, Atsushi Takeno, Tomoki Makino, Keijiro Sugimura, Takushi Yasuda, Yuichiro Doki   +9 more
wiley   +1 more source

Perioperative outcomes of esophagectomy after doublet versus docetaxel‐based triplet neoadjuvant chemotherapy in older patients: A nationwide inpatient database study in Japan

Annals of Gastroenterological Surgery, EarlyView.
In this nationwide inpatient database study of 5229 patients aged 70–79 years who underwent esophagectomy for cancer after neoadjuvant chemotherapy, overlap propensity score weighting analysis showed that neoadjuvant docetaxel‐based triplet regimen (docetaxel, cisplatin, and 5‐fluorouracil) was not associated with a higher incidence of perioperative ...
Yuki Hirano, Takaaki Konishi, Hidehiro Kaneko, Satoru Matsuda, Hirofumi Kawakubo, Yuya Kimura, Hiroki Matsui, Kiyohide Fushimi, Hiroyuki Daiko, Osamu Itano, Hideo Yasunaga, Yuko Kitagawa   +11 more
wiley   +1 more source

Light‐emitting diode irradiation targets aerobic glycolysis in cancer‐associated fibroblasts to inhibit metabolic coupling with colon cancer cells

Annals of Gastroenterological Surgery, EarlyView.
Blue LED irradiation targeted metabolic coupling between CAFs and colon cancer cells. Abstract Background The concepts examined in tumor metabolism research have been moving away from cancer cells themselves and the tumor microenvironment has become a focus of investigation.
Masaaki Nishi, Chiharu Nakasu, Toshiaki Yoshimoto, Takuya Tokunaga, T. Hideya Kashihara, Chie Takasu, Daichi Ishikawa, Yuma Wada, Mitsuo Shimada   +8 more
wiley   +1 more source

Fluorescence Guided Surgery in Gastric Cancer: What Do We Have and What Can We Do?

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background and Objective Fluorescence imaging has emerged as a valuable adjunct in gastric surgery, enhancing resection precision and oncologic outcomes. However, the use of indocyanine green (ICG) remains controversial due to uncertainties in efficacy and administration. A lack of standardized protocols persists.
Chun Zhuang, Han‐Kwang Yang
wiley   +1 more source

Turning on the Heat by Cocrystal Engineering: The Rise of Organic Charge Transfer Photothermal Cocrystals as an Emerging Therapeutic Frontier in Biomedical Application

Aggregate, EarlyView.
This review summarizes recent developments in the design of photothermal charge transfer cocrystals for antibacterial therapy, cancer eradication, and bone regeneration, highlighting the design motivations and chemical principles of the strategies. It offers deep insights into the future development of advanced photothermal cocrystals for targeted ...
Arshad Khan, Rabia Usman, Shuo Xiang, Yasinalli Tamboli, Muhammad Umair, Awatef M. Alshehri, Ibraheem Bushnak, Yan Deng, Nongyue He   +8 more
wiley   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source

Interpretable Active Learning Identifies Iron‐Doped Carbon Dots With High Photothermal Conversion Efficiency for Antitumor Synergistic Therapy

Aggregate, EarlyView.
On the basis of active learning strategy, we propose an equivalent value—SHapley Additive exPlanations equivalent value—to optimize carbon dots’ photothermal conversion efficiency. Within four iterations, iron‐doped carbon dots are synthesized with the efficiency exceeding 78.7%.
Tianliang Li, Bin Cao, Yitong Wang, Lixing Lin, Lifei Chen, Tianhao Su, Haicheng Song, Yuze Ren, Longhan Zhang, Yingying Chen, Zhenzhen Li, Lingyan Feng, Tong‐yi Zhang   +12 more
wiley   +1 more source

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Angewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker, Adrian Pui Ting Ho, Laura S. Itzhaki, Ljiljana Fruk   +3 more
wiley   +2 more sources