Results 181 to 190 of about 288,402 (222)

Mitochondria‐Catalyzed Activation of Anticancer Prodrugs

ChemCatChem, Accepted Article.
Mitochondria mediate electron transport chain (ETC) to power ATP synthase. In cancer cells, the ETC is disturbed leading to leakage of electron that ultimately results in generation of H2O2. This difference between cancer and healthy cells can be used for the design of cancer‐specific prodrugs as confirmed in several proof‐of‐concept studies ...
Michael Raucheisen, Dina Attia, Marlies Körber, Alejandra Aroca Crevillén, Andrés Hidalgo, Frank Beierlein, Petra Imhof, Andriy Mokhir   +7 more
wiley   +1 more source

NEPA (Netupitant/Palonosetron) for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Patients Receiving Highly or Moderately Emetogenic Chemotherapy Who Experienced Breakthrough CINV in Cycle 1 of Chemotherapy: A Phase II Clinical Trial. [PDF]

Cancer Med
Navari RM, Bonizzoni E.
europepmc   +1 more source

Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan‐Degrader

ChemMedChem, EarlyView.
This study introduced DCAF11 as an E3 ligase for PROTAC‐mediated histone deacetylase (HDAC) degradation. By replacing cereblon with DCAF11 as recruited E3 ligase, a selective HDAC6 degrader (A6) was transformed into pan‐HDAC degraders. The lead compound, 1j (FF2039), potently degraded HDACs from classes I, IIa, and IIb, showing strong antiproliferative
Felix Feller, Heiko Weber, Martina Miranda, Irina Honin, Maria Hanl, Finn K. Hansen   +5 more
wiley   +1 more source

Baseline Inflammatory Burden Index Predicts Primary Resistance to Combinations of ICIs With Chemotherapy in Patients With HER-2-Negative Advanced Gastric Cancer. [PDF]

J Gastric Cancer
Wang T, Zeng H, Hu T, Zhang J, Wang Z.
europepmc   +1 more source

Significant Tumor Inhibition of Trimethyl‐152‐[L‐aspartyl]pheophorbide a in Tumor Photodynamic Therapy≠

ChemMedChem, EarlyView.
Novel pheophorbide A, a chlorophyll‐derived compound was prepared by simple and sustainable synthesis. Small structural change to known molecules has a profound effect on the PDT efficacy and its phototoxicity is substantially higher than reference compound m‐THPC.
Anita Benić, Akmaral Kussayeva, Ivana Antol, Mario Vazdar, Zlatko Brkljača, Dan‐Ye Chen, Yi‐Jia Yan, Ying‐Hua Gao, Zhi‐Long Chen, Davor Margetić   +9 more
wiley   +1 more source

Comparison of the Efficacy of 15- and 19-Week Chemotherapy Protocols Based on Vincristine, L-Asparaginase, Doxorubicin, and Prednisolone for Dogs with Multicentric Lymphoma. [PDF]

Animals (Basel)
Lin YC, Wang SL.
europepmc   +1 more source

No operation after short-course radiotherapy followed by consolidation chemotherapy in locally advanced rectal cancer (NOAHS-ARC): study protocol for a prospective, phase II trial. [PDF]

Int J Colorectal Dis
Quezada-Díaz FF, Bercz A, Escobar JL, Caire N, Díaz-Feldman LE, Manriquez E, Carvajal G.   +6 more
europepmc   +1 more source

Chemotherapy and Heart-Specific Mortality in Elderly Men with Prostate Cancer: A Propensity Score Matching Analysis. [PDF]

PLoS One
Zhanghuang C, Wang H, Wang J, Li L, Li J, Hao Z, Zhang J, Liu L, Yan B.   +8 more
europepmc   +1 more source

Sustainable Synthesis, Characterization, Cellular Effects of Gold Nanoparticles and Their Applications as Therapeutics in Cancer Therapy

ChemPlusChem, Accepted Article.
In recent years, gold nanoparticles (AuNPs) have attracted much attention due to their extensive applications in fields such as biomedicine, electronics, catalysis, and environmental science. However, traditional chemical methods for AuNPs synthesis present certain challenges, such as the use of harsh chemicals and high energy consumption.
Youfeng Yue, Akihiro Moriyama, Marie Mita, Yue Yu   +3 more
wiley   +1 more source

Complete response of advanced esophageal squamous cell carcinoma with first-line chemotherapy combined with immunotherapy: a Case report. [PDF]

Front Immunol
Wei Y, Han S, Shi Y, Li Y, Zhang Q, Zhang L, Cheng Y, Yan X, Jia Y.   +8 more
europepmc   +1 more source