Results 291 to 300 of about 1,727,466 (341)

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Bioactive Properties of Algerian Bee Pollen: Influence of Botanical Origin on Polyphenol Content and Antioxidant Capacity. [PDF]

Foods
Saker Y, Escuredo O, Seijo MC, Harbane S, Ouelhadj A, Rodríguez-Flores MS.   +5 more
europepmc   +1 more source

Investigating Mitochondrial Viscosity in Ferroptosis‐Mediated Drug‐Induced Liver Injury using a Double‐Targeted Strategy

Advanced Science, EarlyView.
Utilizing a mitochondrial double‐targeted strategy, a novel near‐infrared fluorescent probe (FTZ‐2) is established for monitoring viscosity variations in ferroptosis‐mediated drug‐induced liver injury. In summary, this work provided a practical strategy for the early diagnosis and evaluation of liver injury.
Yongqing Zhou, Yan Wang, Bing Huang, Hosoowi Lee, Mei Yan, Juyoung Yoon   +5 more
wiley   +1 more source

Polyphenols from Byproducts: Their Applications and Health Effects. [PDF]

Antioxidants (Basel)
Demir R, Sarıtaş S, Bechelany M, Karav S.   +3 more
europepmc   +1 more source

Emerging Therapeutic Strategies for Nrf2-Associated Skin Disorders: From Photoaging to Autoimmunity. [PDF]

Antioxidants (Basel)
Kim HJ, Hong JH.
europepmc   +1 more source

Anti-nutrient factors, nutritional components, and antioxidant activities of faba beans (Vicia faba L.) as affected by genotype, seed traits, and their interactions

Yu‐Mi Choi, Myoung‐Jae Shin, Sukyeung Lee, Hyemyeong Yoon, Jungyoon Yi, Xiaohan Wang, Heon‐Woong Kim, Kebede Taye Desta   +7 more
openalex   +1 more source

Therapy to teratology: chronic paternal antioxidant supplementation alters offspring placental architecture and craniofacial morphogenesis in a mouse model. [PDF]

Front Cell Dev Biol
Derrico DD, Scaturro KZ, Murray EE, Guillen E, Truss NS, Fairly KA, Higgins SL, Bhadsavle SS, Golding MC.   +8 more
europepmc   +1 more source

Antioxidants and Exercise Performance: Focus on Mediterranean Diet. [PDF]

Antioxidants (Basel)
Annunziata G, Camajani E, Galasso M, Verde L, Caprio M, Muscogiuri G, Paoli A, Barrea L.   +7 more
europepmc   +1 more source

Phenolic Composition and Antioxidant Properties of Bee Bread Collected in Three Consecutive Beekeeping Seasons in Poland. [PDF]

Molecules
Szczęsna T, Jaśkiewicz K, Skubij N, Jachuła J.   +3 more
europepmc   +1 more source