Results 241 to 250 of about 617,591 (305)

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Plant-Derived Bioactive Compounds: Antioxidation, Autophagy, and Translational Applications in Skin Protection. [PDF]

Curr Issues Mol Biol
Zhu L, Li M, Wei D, Zhou L.
europepmc   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Integrated quantum chemical and <i>in vitro</i> investigation of Capsanthin antioxidant activity: Mechanism (HAT), cultivar variability, enhanced bioavailability, and key gene expression in peppers. [PDF]

Food Chem (Oxf)
Zhang Y, Bai Y, Cheng L, Hu Y, Lv J, Ren Y, Guo F, Lu J, Wang G.   +8 more
europepmc   +1 more source

A review of the sirtuins family: pivotal regulators and emerging therapeutic targets in renal fibrosis. [PDF]

Ren Fail
Deng Q, Li C, Luo J, Yin M, Qian S, Li L.   +5 more
europepmc   +1 more source

Tannins as Therapeutic Agents for Ulcerative Colitis: Mechanisms and Prospects in Regulating Gut Inflammatory-Oxidative Homeostasis. [PDF]

Molecules
Li Y, Sun C, Hao F, Wang Y, Zhu J, Ming Y, Tian M, Li L, Qian H.   +8 more
europepmc   +1 more source