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Antiphospholipid antibodies and antiphospholipid syndrome
Current Opinion in Rheumatology, 1995More than a decade has gone by since the detailed clinical description of antiphospholipid syndrome (APS). Thrombosis, the main complication of the syndrome, can affect vessels of all sizes; the consistent histopathologic lesion is a bland thrombus without inflammation.
M A, Khamashta, G R, Hughes
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Antiphospholipid antibodies and the antiphospholipid syndrome
Springer Seminars in Immunopathology, 1994The study of aPL antibodies and the APS has appealed to large numbers of investigators over the last decade. This accounts, in part, for the great degree of apparently contradictory data being published. What seems certain is that these antibodies are associated with thrombosis and recurrent pregnancy loss, and animal data suggest a direct role in ...
E N, Harris, S S, Pierangeli
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The Diagnosis of the Antiphospholipid Syndrome
Pathophysiology of Haemostasis and Thrombosis, 2006The concurrence of antiphospholipid (aPL) antibodies and thrombosis or pregnancy loss defines the 'antiphospholipid syndrome' (APS). The Sydney update of the classification criteria for definite APS diagnosis introduced numerous ameliorations to the previous preliminary consensus statement.
PENGO, VITTORIO +2 more
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Lupus, 1996
The antiphospholipid syndrome, now 13 years old, embraces almost all specialties. After a slow start—possibly because many early descriptions were published largely in the rheumatology literature, the syndrome has become recognised worldwide as a major cause of venous-arterial thrombosis, strokes, valvular disease and recurrent abortion. Its prevalence
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The antiphospholipid syndrome, now 13 years old, embraces almost all specialties. After a slow start—possibly because many early descriptions were published largely in the rheumatology literature, the syndrome has become recognised worldwide as a major cause of venous-arterial thrombosis, strokes, valvular disease and recurrent abortion. Its prevalence
openaire +2 more sources
Antiphospholipid syndrome, antiphospholipid antibodies, and atherosclerosis
Current Atherosclerosis Reports, 2001The antiphospholipid syndrome is characterized by arterial and venous thrombosis, as well as pregnancy morbidity, in the presence of elevated levels of antiphospholipid antibodies. These autoantibodies have procoagulant activity, as they affect platelets, humoral coagulation factors, and endothelial cells.
Y, Sherer, Y, Shoenfeld
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Atherogenic Antiphospholipid Antibodies in Antiphospholipid Syndrome
Annals of the New York Academy of Sciences, 2007Abstract: Macrophage uptake of oxidized LDL (oxLDL) plays a critical role in early stages of atherosclerosis. We previously reported that oxLDL forms stable complexes with β2‐glycoprotein I (β2GPI), and that these complexes were frequently present in the sera of patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS ...
Kazuko, Kobayashi +2 more
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Antiphospholipid antibodies and the antiphospholipid antibody syndrome
Drugs of Today, 2000The antiphospholipid antibody syndrome is a multisystem disorder characterized by persistently elevated antiphospholipid antibodies and/or arterial or venous thrombosis, thrombocytopenia and recurrent spontaneous abortion. Anticardiolipin antibodies and the lupus anticoagulant are different classes of antiphospholipid antibodies associated with this ...
G T, Nahass, S L, Jensen
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Hematology, 2003
Abstract The antiphospholipid syndrome (APS) is an autoimmune thrombophilic condition that is marked by the presence of antibodies that recognize phospholipid-binding proteins. The clinical manifestations of APS include vascular thrombosis and pregnancy complications, especially recurrent spontaneous miscarriages.
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Abstract The antiphospholipid syndrome (APS) is an autoimmune thrombophilic condition that is marked by the presence of antibodies that recognize phospholipid-binding proteins. The clinical manifestations of APS include vascular thrombosis and pregnancy complications, especially recurrent spontaneous miscarriages.
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ANTIPHOSPHOLIPID ANTIBODY SYNDROME
Rheumatic Disease Clinics of North America, 1992The antiphospholipid syndrome is now well recognized and is separable from SLE, but better quantitation of both the clinical elements and the serologic definitions is still needed. It is likely for autoimmune but not for infection-induced aPL that the antigen is not phospholipid itself but a complex formed by phospholipid and beta 2 glycoprotein I ...
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Zeitschrift für Rheumatologie, 2007
Antiphospholipid syndrome (APS) is characterized by recurrent arterial or venous thromboembolism or pregnancy loss in association with antibodies directed against anionic phospholipids or plasma proteins bound to anionic phospholipids. A common cause of the huge variety of clinical manifestations is vaso-occlusive disease and not vasculitis in venous ...
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Antiphospholipid syndrome (APS) is characterized by recurrent arterial or venous thromboembolism or pregnancy loss in association with antibodies directed against anionic phospholipids or plasma proteins bound to anionic phospholipids. A common cause of the huge variety of clinical manifestations is vaso-occlusive disease and not vasculitis in venous ...
openaire +5 more sources