Results 71 to 80 of about 36,976 (227)

Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9‐mediated R‐loop resolution

iMeta, EarlyView.
This study suggests that the food‐derived flavonoid hyperoside may act as a natural DExH‐box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R‐loop accumulation. Consequently, it suppresses cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐driven endometrial stromal senescence and restores ...
Yuepeng Jiang, Hongli Zhao, Xinyi Ding, Haoling Zhang, Yadong Guo, Yiming Ma, Lingyi Cai, Qingnan Fan, Ruisi Peng, Fuyuan Yang, Doblin Sandai, Xianling Cao, Jiali Yao, Wenyi Wang, Zhiheng Lin, Wangzheqi Zhang, Jialin He, Aihua Zhang, Xiaoxuan Zhao   +18 more
wiley   +1 more source

INFLUENCE OF FINGOLIMOD ON NON-RESPIRATORY FUNCTIONS OF LUNGS IN ANTIPHOSPHOLIPID SYNDROME

Медицина в Кузбассе, 2021
Objective – the role of immunosuppressive mechanisms in the correction of respiratory system dysfunctions associated with autoimmune pathology (antiphospholipid syndrome).
Мария Анатольевна Уракова, Ирина Георгиевна Брындина   +1 more
doaj  

Antiphospholipid Antibody Syndrome [PDF]

, 2011
Antiphospholipid antibodies are directed against phospholipid-protein complexes and include lupus anticoagulant, anticardiolipin antibodies, and anti–beta-2 glycoprotein I antibodies.
Kristi J Smock, Nikhil A Sangle
core   +1 more source

Preliminary Evaluation of a Novel Lupus Anticoagulant Activity Assay Unaffected by Anticoagulants

Journal of Clinical Laboratory Analysis, EarlyView.
A novel one‐step lupus anticoagulant (LA) assay based on the LA‐sensitivity ratio (LA‐SR) was developed to simplify diagnostic testing and reduce potential interference from anticoagulants. The LA‐SR method showed good agreement with guideline‐based LA testing (dRVVT and/or LA‐sensitive APTT) for the detection of LA and demonstrated limited influence ...
Ayu Hidaka, Risa Kaneshige, Seika Nakamura, Yukari Motoki, Junzo Nojima   +4 more
wiley   +1 more source

Post-partum cutaneous manifestation of antiphospholipid syndrome

Human Pathology: Case Reports, 2019
Antiphospholipid syndrome is a systemic autoimmune disease defined by thrombotic or obstetrical events that occur in patients with persistent antiphospholipid antibodies. The most common dermatologic presentation is livedo reticularis.
Yumeng Zhang, Nicole D. Riddle, Lucia Seminario-Vidal   +2 more
doaj   +1 more source

Churg–Strauss syndrome associated with antiphospholipid antibodies in a patient with recurrent myocardial and cerebral ischemia [PDF]

, 2012
Marino Paroli,1 Alessandro Polidoro,1 Simone Romano,1 Daniele Accapezzato21Department of Biotechnology and Medical-Surgical Sciences, 2Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, ItalyAbstract: We report on
Accapezzato D, Polidoro A, Paroli M, Romano S   +3 more
core  

TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors.
Ling‐Ying Lu, Ling‐Jung Yen, Hui‐Ling Hsia, Zi‐Xeng Weng, Chi‐Hsiang Chung, Paul Wei‐Che Hsu, Chih‐Wei Chiu, Wu‐Chien Chien, Tsung‐Hsien Chang   +8 more
wiley   +1 more source

Survival After Catastrophic Antiphospholipid Syndrome With Diffuse Alveolar Hemorrhage

Journal of Investigative Medicine High Impact Case Reports
Antiphospholipid syndrome is a systemic autoimmune disorder characterized by thrombotic events in the presence of antiphospholipid antibodies including lupus anticoagulant, anticardiolipin, and anti-β2-glycoprotein I antibodies.
Edy Quizhpe, Franklin Uguña, Javier Velastegui, José Luis Santana, Nelson Moran, Miguel Ochoa, Alex Robalino   +6 more
doaj   +1 more source

Role of defensins in immunothrombosis

Rheumatology &Autoimmunity, EarlyView.
Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang, Guijuan Guo, Xiangjun Liu, Xiaoyu Chen, Wenqiong Wang, Patapong Towiwat, Ru Li, Chun Li   +7 more
wiley   +1 more source

Antiphospholipid syndrome patients and antiphospholipid antibody (aPL)-binding characteristics. [PDF]

, 2019
Antiphospholipid syndrome patients and antiphospholipid antibody (aPL)-binding characteristics.
Paul Billoir (6458660), Robinson Joannides (6458672), Louise Damian (6458663), Sébastien Miranda (6458657), Ygal Benhamou (6458675), Pierre Alain Thiebaut (6458666), Maelle Le Besnerais (6458669), Damien Schapman (5846201), Fabienne Jouen (12613), Hervé Levesque (87796), Vincent Richard (138334), Ludovic Galas (711590), Véronique Le Cam-Duchez (58678)   +12 more
core   +1 more source