Results 221 to 230 of about 106,790 (296)

The use of different types of networks, alone and in combination, for drug target identification

British Journal of Pharmacology, EarlyView.
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley   +1 more source

Efficacy of electroconvulsive therapy in treating auditory verbal hallucinations in a deaf patient with schizophrenia: A case report. [PDF]

World J Psychiatry
Wang J, Li J, Wei YG, Lu XX, Zhang ZH.
europepmc   +1 more source

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada, Ruri Okubo, Eishi Motomura   +2 more
wiley   +1 more source

Efficacy and tolerability of pharmacological interventions for schizophrenia non-responsive to prior treatment: a systematic review and network meta-analysis. [PDF]

EClinicalMedicine
Samara M, Lappas AS, Pinioti E, Glarou E, Fober I, Christogiannis C, Siafis S, Christodoulou N, Helfer B, Mavridis D, Leucht S.   +10 more
europepmc   +1 more source

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

Biological Reviews, EarlyView.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett, A. Ross Brown, Samuel K. Maynard, Stewart F. Owen, Charles R. Tyler   +4 more
wiley   +1 more source

Management of Refractory Catatonia Associated With OCD Exacerbation in a Patient With Bipolar I Disorder: A Case Report

Bipolar Disorders, EarlyView.
Jiyun Lee, Rahat Hossain, Nikola Grujich, Ayal Schaffer   +3 more
wiley   +1 more source

Response – Building on existing knowledge and redefining rather than abandoning the well‐established ‘clinical high risk for psychosis’ prevention paradigm

Child and Adolescent Mental Health, EarlyView.
We appreciate the commentary by Tiffin and Kelleher on our systematic review and meta‐analysis. The CHR‐P paradigm remains one of the most established preventive approaches in mental health. While concerns have been raised regarding the clinical utility of the CHR‐P paradigm, its implementation in specialized services worldwide supports its relevance ...
Gonzalo Salazar de Pablo, Claudia Aymerich, Grace Frearson, Javier de Otazu Olivares, Ana Catalan   +4 more
wiley   +1 more source