Results 101 to 110 of about 133,012 (307)

Antipsychotics [PDF]

Journal of Pain and Symptom Management, 2011
Paul, Howard, Robert, Twycross, John, Shuster, Mary, Mihalyo, Andrew, Wilcock   +4 more
openaire   +2 more sources

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Lipids in Health and Disease, 2020
Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics.
Francky Teddy Endomba, Aurel T. Tankeu, Jan René Nkeck, Joel Noutakdie Tochie   +3 more
doaj   +1 more source

Can We Really Prevent Suicide? [PDF]

, 2012
Every year, suicide is among the top 20 leading causes of death globally for all ages. Unfortunately, suicide is difficult to prevent, in large part because the prevalence of risk factors is high among the general population. In this review, clinical and
A Fagiolini, A Roy, A Roy, AC Leon, AD Lopez, AF Jorm, AL Beautrais, AN Sabo, AP Chioqueta, B Schneider, B Schneider, B Spivac, B Stanely, B Stanley, B Yerevanian, BA Palmer, BN Gaynes, C Bushe, C Haw, CM Feltz-Cornelis van der, CW Tsai, D Fergusson, D Gunnell, D Shaffer, D Wasserman, DA Brent, DA Brent, DA Brent, EC Harris, F Cassidy, F Guzzetta, F Keller, FK Goodwin, FS Bridges, G Dieserud, G Isacsson, G Isacsson, G Sonneck, Gil Zalsman, GK Brown, GL Carter, GL Sidley, H Dumesnil, H Galfalvy, H Valtonen, HG Morgan, HJ Moller, HJ Moller, HJ Moller, HY Meltzer, J Fawcet, J Johnson, J Lonnqvist, JA Egeland, JB Luoma, JD Maser, JJ Lin, JJ Mann, JJ Mann, JM Boden, JMG Williams, K Hawton, K Hor, K Posner, K Szanto, KL Knox, KM Malone, L Tondo, LM Hayes, Lucas Giner, M Bauer, M Bauer, M Leitner, M Miller, M Olfson, M Panagioti, M Pompili, M Sarchiapone, M Shelef, MA Oquendo, MA Oquendo, MA Oquendo, MA Oquendo, Maria A. Oquendo, Maya Schwartz-Lifshitz, MD Rudd, MM Linehan, MP Pignone, N Tarrier, ND Kapusta, NM Melhem, O Bennewith, PA Wyman, PG Placidi, PH Soloff, PH Soloff, RD Gibbons, RJ Baldessarini, S Kelly, SH Kennedy, SP Pirkola, U Hegerl, U Hegerl, U Hegerl, UA Andersen, W Coryell, WA Watson, WD Hall, Z Rihmer, Z Rihmer, Z Rihmer, Z Rihmer   +111 more
core   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Psychotropic medication use in Swiss nursing homes

Swiss Medical Weekly, 2011
BACKGROUND: Psychotropic medication is commonly used in nursing homes, to treat behavioural and psychological symptoms of dementia (BPSD) for example.
I Lustenberger, B Schüpbach
doaj   +1 more source

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

Denosumab Offers Relatively Lower Initial Protection Against Osteoporotic Vertebral Fractures in Treatment‐Naive Patients Compared With Zoledronate

Clinical Pharmacology &Therapeutics, EarlyView.
We compared the initial efficacy of denosumab (Dmab) and zoledronate (ZOL) in treatment‐naive patients with osteoporosis. This cohort study, based on TriNetX data, evaluated the risks of fractures and mortality using Kaplan–Meier survival analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs).
Ko‐Hsiu Lu, Shiow‐Ing Wang, Shun‐Fa Yang   +2 more
wiley   +1 more source

Challenges and pitfalls of antipsychotic prescribing in people with learning disability [PDF]

, 2017
No abstract ...
Alexander, Regi T., Bhaumik, Sabyasachi, Cooper, Sally A., Hastings, Richard, Kapugama, Chaya L., Roy, Ashok, Shankar, Rohit, Tromans, Samuel J.   +7 more
core   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, EarlyView.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source