Results 71 to 80 of about 46,487 (292)
British Journal of Clinical Pharmacology, EarlyView.Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber +7 more
wiley +1 more source
Current and Emerging Therapies for the Management of Bipolar Disorders
Journal of Central Nervous System Disease, 2011 Bipolar disorder is a complex condition to treat because agents that may be effective for a specific phase may not be effective for other phases, or may even worsen the overall course of the illness.
Rif S. El-Mallakh +4 more
doaj +1 more source
Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders
Bulletin of the Korean Chemical Society, EarlyView.5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley +1 more source
The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents
IBRO Reports, 2019 This study was designed with the rational aim of discussing the emerging antidepressant agents that are likely to bring positive landmark, tremendous improvement and significant impact to the management of patients with depression disorders.
Olumuyiwa John Fasipe
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer +24 more
wiley +1 more source
The association between hormones and antipsychotic use: a focus on postpartum and menopausal women
Therapeutic Advances in Psychopharmacology, 2019 During the postpartum and menopausal periods of women’s lives, there is a well-established and significant drop of circulating estrogens. This may be the reason why both these periods are associated with an increased risk for onset or exacerbation of ...
Alexandre González-Rodríguez +1 more
doaj +1 more source
Extracellular free water and glutathione in first-episode psychosis-a multimodal investigation of an inflammatory model for psychosis. [PDF]
, 2021 Evidence has been accumulating for an immune-based component to the etiology of psychotic disorders. Advancements in diffusion magnetic resonance imaging (MRI) have enabled estimation of extracellular free water (FW), a putative biomarker of ...
Carter, Cameron S +7 more
core
Clinical Pharmacology &Therapeutics, EarlyView.Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou +7 more
wiley +1 more source
Effect of Concomitant 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor Therapy on Creatine Phosphokinase Levels and Mortality Among Patients Receiving Daptomycin: Retrospective Cohort Study. [PDF]
, 2014 IntroductionThe prescribing information for daptomycin recommends discontinuing statin therapy during receipt of daptomycin. The literature supporting this recommendation is sparse.
Lodise, Thomas +4 more
core +1 more source
Drug Critical Limits for Urgent Physician Notification
Clinical Pharmacology &Therapeutics, EarlyView.Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang +3 more
wiley +1 more source